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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3003
Target Type SINGLE PROTEIN
Preferred Name Nuclear factor NF-kappa-B p100/p49 subunits
Synonyms DNA-binding factor KBF2 | H2TF1 | LYT10 | Lymphocyte translocation chromosome 10 protein | Lyt10 | NFKB2 | Nuclear factor NF-kappa-B p100 subunit | Nuclear factor NF-kappa-B p52 subunit | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 | Oncogene Lyt-10
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein
  • transcription factor

Target Components

Component Description Relationship Accession
Nuclear factor NF-kappa-B p100 subunit SINGLE PROTEIN Q00653

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094258 Nuclear factor NF-kappa-B complex PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000077150
Ensembl ENSG00000077150
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0033257 (Bcl3/NF-kappaB2 complex)
GO Molecular Function GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003713 (transcription coactivator activity)
GO:0005515 (protein binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0002268 (follicular dendritic cell differentiation)
GO:0002467 (germinal center formation)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0007249 (I-kappaB kinase/NF-kappaB signaling)
GO:0007568 (aging)
GO:0030198 (extracellular matrix organization)
GO:0032481 (positive regulation of type I interferon production)
GO:0032496 (response to lipopolysaccharide)
GO:0034097 (response to cytokine)
GO:0038061 (NIK/NF-kappaB signaling)
GO:0045087 (innate immune response)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048511 (rhythmic process)
GO:0048536 (spleen development)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
Wikipedia NFKB2

Target Cross References - Protein

canSAR Q00653
Human Protein Atlas ENSG00000077150
IntAct Q00653
Open Targets ENSG00000077150
PharmGKB PA31600
Reactome R-HSA-1810476 (RIP-mediated NFkB activation via ZBP1.)
R-HSA-3134963 (DEx/H-box helicases activate type I IFN and inflammatory cytokines production.)
R-HSA-3214841 (PKMTs methylate histone lysines.)
R-HSA-445989 (TAK1 activates NFkB by phosphorylation and activation of IKKs complex.)
R-HSA-448706 (Interleukin-1 processing.)
R-HSA-5603027 (IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR).)
R-HSA-5603029 (IkBA variant leads to EDA-ID.)
R-HSA-5607761 (Dectin-1 mediated noncanonical NF-kB signaling.)
R-HSA-5676590 (NIK-->noncanonical NF-kB signaling.)
R-HSA-933542 (TRAF6 mediated NF-kB activation.)
UniProt A8K9D9 D3DR83 Q00653 Q04860 Q9BU75 Q9H471 Q9H472

Target Cross References - Domain

InterPro IPR000451 (NFkB/Dor.)
IPR000488 (Death_domain.)
IPR002110 (Ankyrin_rpt.)
IPR002909 (IPT.)
IPR008967 (p53-like_TF_DNA-bd.)
IPR011029 (DEATH-like_dom.)
IPR011539 (RHD_DNA_bind_dom.)
IPR013783 (Ig-like_fold.)
IPR014756 (Ig_E-set.)
IPR020683 (Ankyrin_rpt-contain_dom.)
IPR030492 (RHD_CS.)
IPR032397 (RHD_dimer.)
IPR033926 (IPT_NFkappaB.)
Pfam PF00531 (Death)
PF00554 (RHD_DNA_bind)
PF12796 (Ank_2)
PF16179 (RHD_dimer)

Target Cross References - Structure

PDBe 1A3Q 3DO7 4OT9
CREDO 1A3Q 3DO7 4OT9
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