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Target Report Card

Target Name and Classification

Target ID CHEMBL2999
Preferred Name Serine/threonine-protein kinase PAK 3
Synonyms Beta-PAK | OPHN3 | Oligophrenin-3 | PAK-3 | PAK3 | Serine/threonine-protein kinase PAK 3 | p21-activated kinase 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase paka subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase PAK 3 SINGLE PROTEIN O75914

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000077264
Ensembl ENSG00000077264
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003824 (catalytic activity)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004702 (receptor signaling protein serine/threonine kinase activity)
GO:0004708 (MAP kinase kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0017048 (Rho GTPase binding)
GO:0017124 (SH3 domain binding)
GO:0046872 (metal ion binding)
GO:0051020 (GTPase binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0000187 (activation of MAPK activity)
GO:0000278 (mitotic cell cycle)
GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0006468 (protein phosphorylation)
GO:0007275 (multicellular organism development)
GO:0007409 (axonogenesis)
GO:0008152 (metabolic process)
GO:0010975 (regulation of neuron projection development)
GO:0016310 (phosphorylation)
GO:0016358 (dendrite development)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0030833 (regulation of actin filament polymerization)
GO:0031295 (T cell costimulation)
GO:0043525 (positive regulation of neuron apoptotic process)
GO:0048013 (ephrin receptor signaling pathway)
GO:0050808 (synapse organization)
GO:0050852 (T cell receptor signaling pathway)
GO:0060996 (dendritic spine development)
GO:0060997 (dendritic spine morphogenesis)
GO:0061003 (positive regulation of dendritic spine morphogenesis)
GO:0071407 (cellular response to organic cyclic compound)
GO:2000573 (positive regulation of DNA biosynthetic process)
Wikipedia PAK3

Target Cross References - Protein

canSAR O75914
CGD Mental retardation, X-linked 30
Human Protein Atlas ENSG00000077264
IntAct O75914
Guide to Pharmacology 2135
Open Targets ENSG00000077264
PharmGKB PA32919
Pharos O75914 (Tchem)
Reactome R-HSA-202433 (Generation of second messenger molecules.)
R-HSA-389359 (CD28 dependent Vav1 pathway.)
R-HSA-3928664 (Ephrin signaling.)
R-HSA-399954 (Sema3A PAK dependent Axon repulsion.)
R-HSA-428540 (Activation of Rac.)
R-HSA-5218920 (VEGFR2 mediated vascular permeability.)
R-HSA-5621575 (CD209 (DC-SIGN) signaling.)
R-HSA-5627123 (RHO GTPases activate PAKs.)
R-HSA-5687128 (MAPK6/MAPK4 signaling.)
UniProt A8K389 B1GX77 B1GX78 B1GX79 O75914 Q5JWX1 Q5JWX2 Q7Z2D6 Q7Z2E4 Q7Z3Z8 Q8WWK5 Q8WX23 Q9P0J8

Target Cross References - Domain

InterPro IPR000095 (CRIB_dom.)
IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR033923 (PAK_BD.)
Pfam PF00069 (Pkinase)
PF00786 (PBD)