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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2999
Preferred Name Serine/threonine-protein kinase PAK 3
Synonyms Beta-PAK | OPHN3 | Oligophrenin-3 | PAK-3 | PAK3 | Serine/threonine-protein kinase PAK 3 | p21-activated kinase 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase paka subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase PAK 3 SINGLE PROTEIN O75914

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000077264
Ensembl ENSG00000077264
GO Molecular Function GO:0004674 (protein serine/threonine kinase activity)
GO:0005524 (ATP binding)
GO:0017124 (SH3 domain binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007275 (multicellular organismal development)
Wikipedia PAK3

Target Cross References - Protein

canSAR O75914
CGD Mental retardation, X-linked 30
Human Protein Atlas ENSG00000077264
IntAct O75914
Guide to Pharmacology 2135 (p21 protein (Cdc42/Rac)-activated kinase 3)
PharmGKB PA32919
Reactome REACT_18266 (Axon guidance.)
UniProt A8K389 B1GX78 B1GX79 O75914 Q5JWX1 Q5JWX2 Q7Z2D6 Q7Z2E4 Q7Z3Z8 Q8WWK5 Q8WX23 Q9P0J8

Target Cross References - Domain

InterPro IPR000095 (PAK_box_Rho-bd.)
IPR000719 (Prot_kinase_cat_dom.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)
PF00786 (PBD)