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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2998
Target Type SINGLE PROTEIN
Preferred Name P2X purinoceptor 3
Synonyms ATP receptor | P2RX3 | P2X purinoceptor 3 | P2X3 | Purinergic receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > p2x receptor

Target Components

Component Description Relationship Accession
P2X purinoceptor 3 SINGLE PROTEIN P56373

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3831281 P2X2/P2X3 heterotrimeric receptor PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545041 AF-219 P2X purinoceptor 3 antagonist 2 Other PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000109991
Ensembl ENSG00000109991
GO Cellular Component GO:0005639 (integral component of nuclear inner membrane)
GO:0005791 (rough endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0043195 (terminal bouton)
GO:0043197 (dendritic spine)
GO:0043235 (receptor complex)
GO:0045121 (membrane raft)
GO Molecular Function GO:0001614 (purinergic nucleotide receptor activity)
GO:0004931 (extracellular ATP-gated cation channel activity)
GO:0005216 (ion channel activity)
GO:0005524 (ATP binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006812 (cation transport)
GO:0007165 (signal transduction)
GO:0007268 (chemical synaptic transmission)
GO:0007274 (neuromuscular synaptic transmission)
GO:0007596 (blood coagulation)
GO:0009266 (response to temperature stimulus)
GO:0009408 (response to heat)
GO:0009409 (response to cold)
GO:0009612 (response to mechanical stimulus)
GO:0009743 (response to carbohydrate)
GO:0010033 (response to organic substance)
GO:0010524 (positive regulation of calcium ion transport into cytosol)
GO:0014832 (urinary bladder smooth muscle contraction)
GO:0019228 (neuronal action potential)
GO:0030432 (peristalsis)
GO:0033198 (response to ATP)
GO:0035590 (purinergic nucleotide receptor signaling pathway)
GO:0048167 (regulation of synaptic plasticity)
GO:0048266 (behavioral response to pain)
GO:0050850 (positive regulation of calcium-mediated signaling)
GO:0050909 (sensory perception of taste)
GO:0051260 (protein homooligomerization)
GO:0061368 (behavioral response to formalin induced pain)
GO:0098655 (cation transmembrane transport)
GO:1904058 (positive regulation of sensory perception of pain)
Wikipedia P2RX3

Target Cross References - Protein

canSAR P56373
Human Protein Atlas ENSG00000109991
Guide to Pharmacology 480
Open Targets ENSG00000109991
PharmGKB PA32863
Pharos P56373 (Tchem)
Reactome R-HSA-139853 (Elevation of cytosolic Ca2+ levels.)
R-HSA-418346 (Platelet homeostasis.)
UniProt P56373 Q6DK37 Q9UQB6

Target Cross References - Domain

InterPro IPR001429 (P2X_purnocptor.)
IPR003046 (P2X3_purnocptor.)
IPR027309 (P2X_extracellular_dom.)
Pfam PF00864 (P2X_receptor)

Target Cross References - Structure

PDBe 5SVJ 5SVK 5SVL 5SVM 5SVP 5SVQ 5SVR 5SVS 5SVT
CREDO 5SVJ 5SVK 5SVL 5SVM 5SVP 5SVQ 5SVR 5SVS 5SVT
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