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Target Report Card

Target Name and Classification

Target ID CHEMBL2996
Target Type SINGLE PROTEIN
Preferred Name Protein kinase C delta
Synonyms PRKCD | Protein kinase C delta type catalytic subunit | Protein kinase C delta type regulatory subunit | Protein kinase C delta type | SDK1 | Sphingosine-dependent protein kinase-1 | Tyrosine-protein kinase PRKCD | nPKC-delta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase pkc family > agc protein kinase pkc delta subfamily

Target Components

Component Description Relationship Accession
Protein kinase C delta type SINGLE PROTEIN Q05655

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2093867 Protein kinase C (PKC) PROTEIN FAMILY
CHEMBL2096620 Protein kinase C, PKC; classical/novel PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2107872 DELCASERTIB Protein kinase C delta inhibitor 2 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000163932
Ensembl ENSG00000163932
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005911 (cell-cell junction)
GO:0016020 (membrane)
GO:0016363 (nuclear matrix)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004697 (protein kinase C activity)
GO:0004699 (calcium-independent protein kinase C activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008047 (enzyme activator activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019899 (enzyme binding)
GO:0019900 (kinase binding)
GO:0019901 (protein kinase binding)
GO:0043560 (insulin receptor substrate binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0006921 (cellular component disassembly involved in execution phase of apoptosis)
GO:0007049 (cell cycle)
GO:0007165 (signal transduction)
GO:0007202 (activation of phospholipase C activity)
GO:0008631 (intrinsic apoptotic signaling pathway in response to oxidative stress)
GO:0010469 (regulation of receptor activity)
GO:0016064 (immunoglobulin mediated immune response)
GO:0016310 (phosphorylation)
GO:0016572 (histone phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0023021 (termination of signal transduction)
GO:0030168 (platelet activation)
GO:0030837 (negative regulation of actin filament polymerization)
GO:0032079 (positive regulation of endodeoxyribonuclease activity)
GO:0032091 (negative regulation of protein binding)
GO:0032147 (activation of protein kinase activity)
GO:0032613 (interleukin-10 production)
GO:0032615 (interleukin-12 production)
GO:0032930 (positive regulation of superoxide anion generation)
GO:0032956 (regulation of actin cytoskeleton organization)
GO:0034351 (negative regulation of glial cell apoptotic process)
GO:0035307 (positive regulation of protein dephosphorylation)
GO:0035556 (intracellular signal transduction)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0042100 (B cell proliferation)
GO:0042119 (neutrophil activation)
GO:0042307 (positive regulation of protein import into nucleus)
GO:0042742 (defense response to bacterium)
GO:0043407 (negative regulation of MAP kinase activity)
GO:0043488 (regulation of mRNA stability)
GO:0046627 (negative regulation of insulin receptor signaling pathway)
GO:0050728 (negative regulation of inflammatory response)
GO:0050732 (negative regulation of peptidyl-tyrosine phosphorylation)
GO:0050821 (protein stabilization)
GO:0051490 (negative regulation of filopodium assembly)
GO:0060326 (cell chemotaxis)
GO:0060333 (interferon-gamma-mediated signaling pathway)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0071447 (cellular response to hydroperoxide)
GO:0090331 (negative regulation of platelet aggregation)
GO:0090398 (cellular senescence)
GO:1900163 (positive regulation of phospholipid scramblase activity)
GO:1904385 (cellular response to angiotensin)
GO:2000304 (positive regulation of ceramide biosynthetic process)
GO:2000753 (positive regulation of glucosylceramide catabolic process)
GO:2000755 (positive regulation of sphingomyelin catabolic process)
GO:2001022 (positive regulation of response to DNA damage stimulus)
GO:2001235 (positive regulation of apoptotic signaling pathway)
Wikipedia PRKCD

Target Cross References - Protein

canSAR Q05655
CGD B-cell deficiency and severe autoimmunity, autosomal recessive, due to protein kinase C delta deficiency
Human Protein Atlas ENSG00000163932
IntAct Q05655
Guide to Pharmacology 1485
Open Targets ENSG00000163932
PharmGKB PA33763
Pharos Q05655 (Tclin)
Reactome R-HSA-111465 (Apoptotic cleavage of cellular proteins.)
R-HSA-111933 (Calmodulin induced events.)
R-HSA-114508 (Effects of PIP2 hydrolysis.)
R-HSA-1250196 (SHC1 events in ERBB2 signaling.)
R-HSA-1489509 (DAG and IP3 signaling.)
R-HSA-2029485 (Role of phospholipids in phagocytosis.)
R-HSA-418597 (G alpha (z) signalling events.)
R-HSA-450520 (HuR (ELAVL1) binds and stabilizes mRNA.)
R-HSA-5218921 (VEGFR2 mediated cell proliferation.)
R-HSA-5607764 (CLEC7A (Dectin-1) signaling.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-877300 (Interferon gamma signaling.)
UniProt B0KZ81 B2R834 Q05655 Q15144 Q86XJ6

Target Cross References - Domain

InterPro IPR000008 (C2_dom.)
IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR002219 (PE/DAG-bd.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR014376 (Prot_kin_PKC_delta.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017892 (Pkinase_C.)
IPR020454 (DAG/PE-bd.)
IPR027436 (PKC_delta.)
Pfam PF00069 (Pkinase)
PF00130 (C1_1)
PF00433 (Pkinase_C)

Target Cross References - Structure

PDBe 1YRK
CREDO 1YRK
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