ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL2996
Target Type SINGLE PROTEIN
Preferred Name Protein kinase C delta
Synonyms PRKCD | Protein kinase C delta type | Protein kinase C delta type catalytic subunit | Protein kinase C delta type regulatory subunit | SDK1 | Sphingosine-dependent protein kinase-1 | Tyrosine-protein kinase PRKCD | nPKC-delta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase pkc family > agc protein kinase pkc delta subfamily

Target Components

Component Description Relationship Accession
Protein kinase C delta type SINGLE PROTEIN Q05655

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096620 Protein kinase C, PKC; classical/novel PROTEIN FAMILY
CHEMBL2093867 Protein kinase C (PKC) PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Expression Atlas ENSG00000163932
Ensembl ENSG00000163932
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005829 (cytosol)
GO Molecular Function GO:0004699 (calcium-independent protein kinase C activity)
GO:0005524 (ATP binding)
GO:0008022 (protein C-terminus binding)
GO:0008047 (enzyme activator activity)
GO:0019899 (enzyme binding)
GO:0043560 (insulin receptor substrate binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006921 (cellular component disassembly involved in apoptosis)
GO:0007202 (activation of phospholipase C activity)
GO:0010469 (regulation of receptor activity)
GO:0016071 (mRNA metabolic process)
GO:0030168 (platelet activation)
GO:0032091 (negative regulation of protein binding)
GO:0035556 (intracellular signal transduction)
GO:0046627 (negative regulation of insulin receptor signaling pathway)
GO:0048011 (nerve growth factor receptor signaling pathway)
GO:0050732 (negative regulation of peptidyl-tyrosine phosphorylation)
GO:0050821 (protein stabilization)
GO:0060333 (interferon-gamma-mediated signaling pathway)
GO:0090398 (cellular senescence)
Wikipedia PRKCD

Target Cross References - Protein

canSAR Q05655
CGD B-cell deficiency and severe autoimmunity, autosomal recessive, due to protein kinase C delta deficiency
Human Protein Atlas ENSG00000163932
IntAct Q05655
Guide to Pharmacology 1485 (protein kinase C, delta)
PharmGKB PA33763
Reactome REACT_11061 (Signalling by NGF.)
REACT_14797 (Signaling by GPCR.)
REACT_15295 (Opioid Signalling.)
REACT_21257 (Metabolism of RNA.)
REACT_578 (Apoptosis.)
REACT_604 (Hemostasis.)
REACT_6900 (Signaling in Immune system.)
UniProt B2R834 Q05655 Q15144 Q86XJ6

Target Cross References - Domain

InterPro IPR000008 (C2_Ca-dep.)
IPR000719 (Prot_kinase_cat_dom.)
IPR000961 (AGC-kinase_C.)
IPR002219 (Prot_Kinase_C-like_PE/DAG-bd.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR008973 (C2_Ca/lipid-bd_dom_CaLB.)
IPR011009 (Kinase-like_dom.)
IPR014376 (Prot_kin_PKC_delta.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
IPR017892 (Pkinase_C.)
IPR020454 (DAG/PE-bd.)
Pfam PF00069 (Pkinase)
PF00130 (C1_1)
PF00433 (Pkinase_C)

Target Cross References - Structure

PDBe 1YRK
CREDO 1YRK
spacer
spacer