ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL2990
Target Type SINGLE PROTEIN
Preferred Name Alcohol dehydrogenase class II
Synonyms Object
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Alcohol dehydrogenase 4 SINGLE PROTEIN P08319

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096668 Alcohol dehydrogenase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198099
Ensembl ENSG00000198099
GO Cellular Component GO:0005829 (cytosol)
GO Molecular Function GO:0003960 (NADPH:quinone reductase activity)
GO:0004022 (alcohol dehydrogenase (NAD) activity)
GO:0004745 (retinol dehydrogenase activity)
GO:0019115 (benzaldehyde dehydrogenase activity)
GO:0051287 (NAD binding)
GO:0004024 (alcohol dehydrogenase activity, zinc-dependent)
GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)
GO:0004032 (alditol:NADP+ 1-oxidoreductase activity)
GO:0005503 (all-trans retinal binding)
GO:0035276 (ethanol binding)
GO:0019841 (retinol binding)
GO:0008270 (zinc ion binding)
GO Biological Process GO:0006066 (alcohol metabolic process)
GO:0044281 (small molecule metabolic process)
GO:0001523 (retinoid metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0046164 (alcohol catabolic process)
GO:1901661 (quinone metabolic process)
GO:0006081 (cellular aldehyde metabolic process)
GO:0006069 (ethanol oxidation)
GO:0042572 (retinol metabolic process)
Wikipedia ADH4

Target Cross References - Protein

Human Protein Atlas ENSG00000198099
IntAct P08319
PharmGKB PA24573
UniProt P08319 Q8TCD7 A8K470 C9J4A9 B4DIE7

Target Cross References - Domain

InterPro IPR028632 (Zinc_ADH_II.)
IPR002085 (ADH_SF_Zn-type.)
IPR002328 (ADH_Zn_CS.)
IPR011032 (GroES-like.)
IPR013154 (ADH_N.)
IPR013149 (ADH_C.)
IPR016040 (NAD(P)-bd_dom.)
Pfam PF00107 (ADH_zinc_N)
PF08240 (ADH_N)

Target Cross References - Structure

PDBe 3COS
CREDO 3COS
spacer
spacer