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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL299
Target Type SINGLE PROTEIN
Preferred Name Protein kinase C alpha
Synonyms PKC-A | PKC-alpha | PKCA | PRKACA | PRKCA | Protein kinase C alpha type
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase pkc family > agc protein kinase pkc alpha subfamily

Target Components

Component Description Relationship Accession
Protein kinase C alpha type SINGLE PROTEIN P17252

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096620 Protein kinase C, PKC; classical/novel PROTEIN FAMILY
CHEMBL3137267 PKC alpha and beta-2 PROTEIN FAMILY
CHEMBL2093867 Protein kinase C (PKC) PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000154229
Ensembl ENSG00000154229
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005783 (endoplasmic reticulum)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0031966 (mitochondrial membrane)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004697 (protein kinase C activity)
GO:0004698 (calcium-dependent protein kinase C activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008270 (zinc ion binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019899 (enzyme binding)
GO:0035403 (histone kinase activity (H3-T6 specific))
GO:0046872 (metal ion binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0002159 (desmosome assembly)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007077 (mitotic nuclear envelope disassembly)
GO:0007155 (cell adhesion)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007194 (negative regulation of adenylate cyclase activity)
GO:0010595 (positive regulation of endothelial cell migration)
GO:0010613 (positive regulation of cardiac muscle hypertrophy)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0030168 (platelet activation)
GO:0030335 (positive regulation of cell migration)
GO:0031666 (positive regulation of lipopolysaccharide-mediated signaling pathway)
GO:0034351 (negative regulation of glial cell apoptotic process)
GO:0035408 (histone H3-T6 phosphorylation)
GO:0035556 (intracellular signal transduction)
GO:0043488 (regulation of mRNA stability)
GO:0043536 (positive regulation of blood vessel endothelial cell migration)
GO:0045651 (positive regulation of macrophage differentiation)
GO:0045766 (positive regulation of angiogenesis)
GO:0045785 (positive regulation of cell adhesion)
GO:0045931 (positive regulation of mitotic cell cycle)
GO:0050796 (regulation of insulin secretion)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0070555 (response to interleukin-1)
GO:0090330 (regulation of platelet aggregation)
GO:0097190 (apoptotic signaling pathway)
GO:2000707 (positive regulation of dense core granule biogenesis)
Wikipedia PKC_alpha

Target Cross References - Protein

Human Protein Atlas ENSG00000154229
IntAct P17252
Guide to Pharmacology 1482
Open Targets ENSG00000154229
PharmGKB PA33759
Pharos P17252 (Tchem)
Reactome R-HSA-111933 (Calmodulin induced events.)
R-HSA-114516 (Disinhibition of SNARE formation.)
R-HSA-1433557 (Signaling by SCF-KIT.)
R-HSA-1433559 (Regulation of KIT signaling.)
R-HSA-2179392 (EGFR Transactivation by Gastrin.)
R-HSA-2514859 (Inactivation, recovery and regulation of the phototransduction cascade.)
R-HSA-3000170 (Syndecan interactions.)
R-HSA-399997 (Acetylcholine regulates insulin secretion.)
R-HSA-4086398 (Ca2+ pathway.)
R-HSA-416993 (Trafficking of GluR2-containing AMPA receptors.)
R-HSA-418597 (G alpha (z) signalling events.)
R-HSA-4419969 (Depolymerisation of the Nuclear Lamina.)
R-HSA-450520 (HuR (ELAVL1) binds and stabilizes mRNA.)
R-HSA-5099900 (WNT5A-dependent internalization of FZD4.)
R-HSA-5218921 (VEGFR2 mediated cell proliferation.)
R-HSA-76005 (Response to elevated platelet cytosolic Ca2+.)
UniProt B5BU22 P17252 Q15137 Q32M72 Q96RE4

Target Cross References - Domain

InterPro IPR000008 (C2_dom.)
IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR002219 (PE/DAG-bd.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR014375 (Protein_kinase_C_a/b/g.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017892 (Pkinase_C.)
IPR020454 (DAG/PE-bd.)
Pfam PF00069 (Pkinase)
PF00130 (C1_1)
PF00168 (C2)
PF00433 (Pkinase_C)

Target Cross References - Structure

PDBe 3IW4 4DNL 4RA4
CREDO 3IW4 4DNL 4RA4
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