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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL299
Target Type SINGLE PROTEIN
Preferred Name Protein kinase C alpha
Synonyms PKC-A | PKC-alpha | PKCA | PRKACA | PRKCA | Protein kinase C alpha type
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase pkc family > agc protein kinase pkc alpha subfamily

Target Components

Component Description Relationship Accession
Protein kinase C alpha type SINGLE PROTEIN P17252

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096620 Protein kinase C, PKC; classical/novel PROTEIN FAMILY
CHEMBL2093867 Protein kinase C (PKC) PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000154229
Ensembl ENSG00000154229
GO Cellular Component GO:0005624 (membrane fraction)
GO:0005654 (nucleoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0004697 (protein kinase C activity)
GO:0005524 (ATP binding)
GO:0008270 (zinc ion binding)
GO:0019899 (enzyme binding)
GO:0035403 (histone kinase activity (H3-T6 specific))
GO Biological Process GO:0006112 (energy reserve metabolic process)
GO:0007202 (activation of phospholipase C activity)
GO:0007268 (synaptic transmission)
GO:0008624 (induction of apoptosis by extracellular signals)
GO:0016071 (mRNA metabolic process)
GO:0030168 (platelet activation)
GO:0035556 (intracellular signal transduction)
GO:0043536 (positive regulation of blood vessel endothelial cell migration)
GO:0048011 (nerve growth factor receptor signaling pathway)
GO:0050796 (regulation of insulin secretion)
GO:0070555 (response to interleukin-1)
Wikipedia PKC_alpha

Target Cross References - Protein

Human Protein Atlas ENSG00000154229
IntAct P17252
PharmGKB PA33759
Reactome REACT_11061 (Signalling by NGF.)
REACT_13685 (Synaptic Transmission.)
REACT_14797 (Signaling by GPCR.)
REACT_1505 (Integration of energy metabolism.)
REACT_15295 (Opioid Signalling.)
REACT_15380 (Diabetes pathways.)
REACT_21257 (Metabolism of RNA.)
REACT_604 (Hemostasis.)
UniProt P17252 Q15137 Q32M72 Q96RE4

Target Cross References - Domain

InterPro IPR000008 (C2_Ca-dep.)
IPR000719 (Prot_kinase_cat_dom.)
IPR000961 (AGC-kinase_C.)
IPR002219 (Prot_Kinase_C-like_PE/DAG-bd.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR008973 (C2_Ca/lipid-bd_dom_CaLB.)
IPR011009 (Kinase-like_dom.)
IPR014375 (Protein_kinase_C_a/b/g.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
IPR017892 (Pkinase_C.)
IPR018029 (C2_membr_targeting.)
IPR020454 (DAG/PE-bd.)
IPR020477 (C2_region.)
Pfam PF00069 (Pkinase)
PF00130 (C1_1)
PF00168 (C2)
PF00433 (Pkinase_C)

Target Cross References - Structure

PDBe 3IW4
CREDO 3IW4
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