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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2979
Target Type SINGLE PROTEIN
Preferred Name Integrin beta-7
Synonyms Gut homing receptor beta subunit | ITGB7 | Integrin beta-7
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Integrin beta-7 SINGLE PROTEIN P26010

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095184 Integrin alpha-4/beta-7 PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1743015 ETROLIZUMAB Integrin beta-7 antagonist 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000139626
Ensembl ENSG00000139626
GO Cellular Component GO:0005886 (plasma membrane)
GO:0008305 (integrin complex)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0034669 (integrin alpha4-beta7 complex)
GO:0043235 (receptor complex)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0001618 (virus receptor activity)
GO:0004872 (receptor activity)
GO:0005515 (protein binding)
GO:0046872 (metal ion binding)
GO:0050839 (cell adhesion molecule binding)
GO Biological Process GO:0003366 (cell-matrix adhesion involved in ameboidal cell migration)
GO:0007155 (cell adhesion)
GO:0007160 (cell-matrix adhesion)
GO:0007229 (integrin-mediated signaling pathway)
GO:0030198 (extracellular matrix organization)
GO:0034113 (heterotypic cell-cell adhesion)
GO:0034446 (substrate adhesion-dependent cell spreading)
GO:0043113 (receptor clustering)
GO:0046718 (viral entry into host cell)
GO:0050776 (regulation of immune response)
GO:0050900 (leukocyte migration)
GO:0050901 (leukocyte tethering or rolling)
GO:0072678 (T cell migration)
Wikipedia ITGB7

Target Cross References - Protein

canSAR P26010
Human Protein Atlas ENSG00000139626
IntAct P26010
Guide to Pharmacology 2461
Open Targets ENSG00000139626
PharmGKB PA29961
Reactome R-HSA-198933 (Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.)
R-HSA-216083 (Integrin cell surface interactions.)
TIMBAL Integrins
UniProt P26010 Q9UCP7 Q9UCS7

Target Cross References - Domain

InterPro IPR002035 (VWF_A.)
IPR002369 (Integrin_bsu_VWA.)
IPR012896 (Integrin_bsu_tail.)
IPR013111 (EGF_extracell.)
IPR014836 (Integrin_bsu_cyt_dom.)
IPR015437 (Integrin_bsu-7.)
IPR015812 (Integrin_bsu.)
IPR016201 (PSI.)
IPR032695 (Integrin_dom.)
IPR033760 (Integin_beta_N.)
Pfam PF00362 (Integrin_beta)
PF07974 (EGF_2)
PF08725 (Integrin_b_cyt)
PF17205 (PSI_integrin)

Target Cross References - Structure

PDBe 2BRQ 3V4P 3V4V
CREDO 2BRQ 3V4P 3V4V
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