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Target Report Card

Target Name and Classification

Target ID CHEMBL2971
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase JAK2
Synonyms JAK-2 | JAK2 | Janus kinase 2 | Tyrosine-protein kinase JAK2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase jakb family
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase jaka family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase JAK2 SINGLE PROTEIN O60674

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3301392 JAK2/TYK2 PROTEIN COMPLEX
CHEMBL3301390 JAK1/JAK2/TYK2 PROTEIN COMPLEX
CHEMBL3038492 JAK2/JAK1 PROTEIN COMPLEX
CHEMBL2363062 Janus Kinase (JAK) PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1795071 RUXOLITINIB PHOSPHATE Tyrosine-protein kinase JAK2 inhibitor 4 FDA
CHEMBL603469 LESTAURTINIB Tyrosine-protein kinase JAK2 inhibitor 3 PubMed
CHEMBL1078178 MOMELOTINIB Tyrosine-protein kinase JAK2 inhibitor 3
CHEMBL1287853 FEDRATINIB Tyrosine-protein kinase JAK2 inhibitor 3
CHEMBL2035187 PACRITINIB Tyrosine-protein kinase JAK2 inhibitor 3 Other PubMed PubMed
CHEMBL2105759 BARICITINIB Tyrosine-protein kinase JAK2 inhibitor 3
CHEMBL495727 AT-9283 Tyrosine-protein kinase JAK2 inhibitor 2
CHEMBL1231124 AZD-1480 Tyrosine-protein kinase JAK2 inhibitor 2 PubMed PubMed
CHEMBL2107823 GANDOTINIB Tyrosine-protein kinase JAK2 inhibitor 2 PubMed
CHEMBL3545024 INCB-39110 Tyrosine-protein kinase JAK2 2
CHEMBL3545215 BMS-911543 Tyrosine-protein kinase JAK2 inhibitor 2 PubMed
CHEMBL3545217 NS-018 Tyrosine-protein kinase JAK2 inhibitor 2 PubMed
CHEMBL1944698 TG-02 Tyrosine-protein kinase JAK2 inhibitor 1
CHEMBL3544962 CT-1578 Tyrosine-protein kinase JAK2 inhibitor 1
CHEMBL3544997 LS-104 Tyrosine-protein kinase JAK2 inhibitor 1 PubMed
CHEMBL3545241 AC-430 Tyrosine-protein kinase JAK2 inhibitor 1 Other
CHEMBL3545328 XL-019 Tyrosine-protein kinase JAK2 inhibitor 1 PubMed PubMed
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000096968
Ensembl ENSG00000096968
GO Cellular Component GO:0005856 (cytoskeleton)
GO:0005654 (nucleoplasm)
GO:0016363 (nuclear matrix)
GO:0005829 (cytosol)
GO:0005634 (nucleus)
GO:0005901 (caveola)
GO:0005737 (cytoplasm)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0031904 (endosome lumen)
GO:0045121 (membrane raft)
GO Molecular Function GO:0005131 (growth hormone receptor binding)
GO:0042393 (histone binding)
GO:0005143 (interleukin-12 receptor binding)
GO:0005102 (receptor binding)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005524 (ATP binding)
GO:0019901 (protein kinase binding)
GO:0004713 (protein tyrosine kinase activity)
GO:0042169 (SH2 domain binding)
GO:0004672 (protein kinase activity)
GO:0020037 (heme binding)
GO:0035401 (histone kinase activity (H3-Y41 specific))
GO Biological Process GO:0000165 (MAPK cascade)
GO:0007262 (STAT protein import into nucleus)
GO:0007498 (mesoderm development)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030218 (erythrocyte differentiation)
GO:0032731 (positive regulation of interleukin-1 beta production)
GO:0033194 (response to hydroperoxide)
GO:0043388 (positive regulation of DNA binding)
GO:0045597 (positive regulation of cell differentiation)
GO:0051091 (positive regulation of sequence-specific DNA binding transcription factor activity)
GO:0060397 (JAK-STAT cascade involved in growth hormone signaling pathway)
GO:0006325 (chromatin organization)
GO:0007165 (signal transduction)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007265 (Ras protein signal transduction)
GO:0007596 (blood coagulation)
GO:0046677 (response to antibiotic)
GO:0050727 (regulation of inflammatory response)
GO:0006468 (protein phosphorylation)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0008286 (insulin receptor signaling pathway)
GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling)
GO:0032760 (positive regulation of tumor necrosis factor production)
GO:0034050 (host programmed cell death induced by symbiont)
GO:0034612 (response to tumor necrosis factor)
GO:0046777 (protein autophosphorylation)
GO:0048011 (neurotrophin TRK receptor signaling pathway)
GO:0051770 (positive regulation of nitric-oxide synthase biosynthetic process)
GO:0061180 (mammary gland epithelium development)
GO:0070671 (response to interleukin-12)
GO:0097191 (extrinsic apoptotic signaling pathway)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0007167 (enzyme linked receptor protein signaling pathway)
GO:0030335 (positive regulation of cell migration)
GO:0031959 (mineralocorticoid receptor signaling pathway)
GO:0035409 (histone H3-Y41 phosphorylation)
GO:0035556 (intracellular signal transduction)
GO:0035722 (interleukin-12-mediated signaling pathway)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0042127 (regulation of cell proliferation)
GO:0042506 (tyrosine phosphorylation of Stat5 protein)
GO:0042508 (tyrosine phosphorylation of Stat1 protein)
GO:0060334 (regulation of interferon-gamma-mediated signaling pathway)
GO:0071549 (cellular response to dexamethasone stimulus)
GO:0097296 (activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)
GO:0006915 (apoptotic process)
GO:0007411 (axon guidance)
GO:0008284 (positive regulation of cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0033209 (tumor necrosis factor-mediated signaling pathway)
GO:0042523 (positive regulation of tyrosine phosphorylation of Stat5 protein)
GO:0042977 (activation of JAK2 kinase activity)
GO:0045087 (innate immune response)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0048008 (platelet-derived growth factor receptor signaling pathway)
GO:0050729 (positive regulation of inflammatory response)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050867 (positive regulation of cell activation)
GO:0060399 (positive regulation of growth hormone receptor signaling pathway)
GO:0007260 (tyrosine phosphorylation of STAT protein)
GO:0008543 (fibroblast growth factor receptor signaling pathway)
GO:0009755 (hormone-mediated signaling pathway)
GO:0010811 (positive regulation of cell-substrate adhesion)
GO:0030041 (actin filament polymerization)
GO:0030154 (cell differentiation)
GO:0031103 (axon regeneration)
GO:0032024 (positive regulation of insulin secretion)
GO:0042503 (tyrosine phosphorylation of Stat3 protein)
GO:0042517 (positive regulation of tyrosine phosphorylation of Stat3 protein)
GO:0045822 (negative regulation of heart contraction)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0060396 (growth hormone receptor signaling pathway)
GO:0000186 (activation of MAPKK activity)
GO:0002250 (adaptive immune response)
GO:0006928 (movement of cell or subcellular component)
GO:0007259 (JAK-STAT cascade)
GO:0010667 (negative regulation of cardiac muscle cell apoptotic process)
GO:0032516 (positive regulation of phosphoprotein phosphatase activity)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0007264 (small GTPase mediated signal transduction)
GO:0008631 (intrinsic apoptotic signaling pathway in response to oxidative stress)
GO:0016477 (cell migration)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0022408 (negative regulation of cell-cell adhesion)
GO:0032496 (response to lipopolysaccharide)
GO:0033160 (positive regulation of protein import into nucleus, translocation)
GO:0042981 (regulation of apoptotic process)
GO:0043392 (negative regulation of DNA binding)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0060333 (interferon-gamma-mediated signaling pathway)
GO:0071222 (cellular response to lipopolysaccharide)
Wikipedia Janus_kinase_2

Target Cross References - Protein

canSAR O60674
CGD Thrombocythemia 3
Human Protein Atlas ENSG00000096968
IntAct O60674
Guide to Pharmacology 2048 (Janus kinase 2)
PharmGKB PA29989
UniProt O75297 O60674 O14636

Target Cross References - Domain

InterPro IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR019748 (FERM_central.)
IPR020693 (Tyr_kinase_non-rcpt_Jak2.)
IPR000719 (Prot_kinase_dom.)
IPR019749 (Band_41_domain.)
IPR016251 (Tyr_kinase_non-rcpt_Jak/Tyk2.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR000299 (FERM_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
Pfam PF07714 (Pkinase_Tyr)
PF00017 (SH2)

Target Cross References - Structure

PDBe 2B7A 3E63 3Q32 4C62 5CF8 3E64 3IOK 4BBE 4D1S 4FVP 4HGE 5AEP 5CF5 2W1I 3LPB 3UGC 3ZMM 4FVQ 4FVR 4YTC 2XA4 3FUP 3KRR 4D0X More...
CREDO 2B7A 3E63 3Q32 4C62 5CF8 3E64 3IOK 4BBE 4D1S 4FVP 4HGE 5AEP 5CF5 2W1I 3LPB 3UGC 3ZMM 4FVQ 4FVR 4YTC 2XA4 3FUP 3KRR 4D0X More...
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