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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2959
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase ITK/TSK
Synonyms EMT | IL-2-inducible T-cell kinase | ITK | Interleukin-2-inducible T-cell kinase | Kinase EMT | LYK | T-cell-specific kinase | Tyrosine-protein kinase ITK/TSK | Tyrosine-protein kinase Lyk
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase tec family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase ITK/TSK SINGLE PROTEIN Q08881

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1201733 PAZOPANIB HYDROCHLORIDE Tyrosine-protein kinase ITK/TSK inhibitor 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000113263
Ensembl ENSG00000113263
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005911 (cell-cell junction)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001816 (cytokine production)
GO:0001865 (NK T cell differentiation)
GO:0002250 (adaptive immune response)
GO:0002376 (immune system process)
GO:0006468 (protein phosphorylation)
GO:0006968 (cellular defense response)
GO:0007165 (signal transduction)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007202 (activation of phospholipase C activity)
GO:0016310 (phosphorylation)
GO:0032609 (interferon-gamma production)
GO:0032633 (interleukin-4 production)
GO:0035556 (intracellular signal transduction)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0042110 (T cell activation)
GO:0042127 (regulation of cell proliferation)
GO:0045087 (innate immune response)
GO:0050852 (T cell receptor signaling pathway)
Wikipedia ITK_(gene)

Target Cross References - Protein

canSAR Q08881
CGD Lymphoproliferative syndrome, EBV-associated, autosomal, 1
Human Protein Atlas ENSG00000113263
IntAct Q08881
Guide to Pharmacology 2046
Open Targets ENSG00000113263
PharmGKB PA29968
Pharos Q08881 (Tclin)
Reactome R-HSA-202433 (Generation of second messenger molecules.)
R-HSA-2871809 (FCERI mediated Ca+2 mobilization.)
UniProt B2R752 Q08881 Q32ML7

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR001562 (Znf_Btk_motif.)
IPR001849 (PH_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR011993 (PH_dom-like.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF00169 (PH)
PF00779 (BTK)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1SM2 1SNU 1SNX 3MIY 3MJ1 3MJ2 3QGW 3QGY 3T9T 3V5J 3V5L 3V8T 3V8W 4HCT 4HCU 4HCV 4KIO 4L7S 4M0Y 4M0Z 4M12 4M13 4M14 4M15 More...
CREDO 1SM2 1SNU 1SNX 3MIY 3MJ1 3MJ2 3QGW 3QGY 3T9T 3V5J 3V5L 3V8T 3V8W 4HCT 4HCU 4HCV 4KIO 4L7S 4M0Y 4M0Z 4M12 4M13 4M14 4M15 More...
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