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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2952
Target Type SINGLE PROTEIN
Preferred Name Glutamate decarboxylase 65 kDa isoform
Synonyms 65 kDa glutamic acid decarboxylase | GAD-65 | GAD2 | GAD65 | Glutamate decarboxylase 2 | Glutamate decarboxylase 65 kDa isoform
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Glutamate decarboxylase 2 SINGLE PROTEIN Q05329

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000136750
Ensembl ENSG00000136750
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016023 (cytoplasmic, membrane-bounded vesicle)
GO:0030054 (cell junction)
GO:0030424 (axon)
GO:0030672 (synaptic vesicle membrane)
GO:0031225 (anchored component of membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0042734 (presynaptic membrane)
GO:0045202 (synapse)
GO:0048471 (perinuclear region of cytoplasm)
GO:0060077 (inhibitory synapse)
GO:0061202 (clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004351 (glutamate decarboxylase activity)
GO:0005515 (protein binding)
GO:0016595 (glutamate binding)
GO:0016829 (lyase activity)
GO:0016831 (carboxy-lyase activity)
GO:0030170 (pyridoxal phosphate binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0006540 (glutamate decarboxylation to succinate)
GO:0007268 (chemical synaptic transmission)
GO:0007269 (neurotransmitter secretion)
GO:0019752 (carboxylic acid metabolic process)
GO:0042136 (neurotransmitter biosynthetic process)
GO:0042493 (response to drug)
Wikipedia GAD2

Target Cross References - Protein

canSAR Q05329
Human Protein Atlas ENSG00000136750
IntAct Q05329
Open Targets ENSG00000136750
PharmGKB PA28508
Reactome R-HSA-888568 (GABA synthesis.)
R-HSA-888590 (GABA synthesis, release, reuptake and degradation.)
UniProt Q05329 Q9UD87

Target Cross References - Domain

InterPro IPR002129 (PyrdxlP-dep_de-COase.)
IPR015421 (PyrdxlP-dep_Trfase_major_sub1.)
IPR015422 (PyrdxlP-dep_Trfase_major_sub2.)
IPR015424 (PyrdxlP-dep_Trfase.)
IPR021115 (Pyridoxal-P_BS.)
Pfam PF00282 (Pyridoxal_deC)

Target Cross References - Structure

PDBe 1ES0 2OKK
CREDO 1ES0 2OKK
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