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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2940
Target Type SINGLE PROTEIN
Preferred Name Immunoglobulin epsilon Fc receptor
Synonyms BLAST-2 | C-type lectin domain family 4 member J | CD23A | CD_antigen=CD23 | CLEC4J | FCE2 | FCER2 | Fc-epsilon-RII | IGEBF | Immunoglobulin E-binding factor | Low affinity immunoglobulin epsilon Fc receptor membrane-bound form | Low affinity immunoglobulin epsilon Fc receptor soluble form | Low affinity immunoglobulin epsilon Fc receptor | Lymphocyte IgE receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Low affinity immunoglobulin epsilon Fc receptor SINGLE PROTEIN P06734

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2109151 LUMILIXIMAB Immunoglobulin epsilon Fc receptor antagonist 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000104921
Ensembl ENSG00000104921
GO Cellular Component GO:0005576 (extracellular region)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0005178 (integrin binding)
GO:0005515 (protein binding)
GO:0019863 (IgE binding)
GO:0030246 (carbohydrate binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0002925 (positive regulation of humoral immune response mediated by circulating immunoglobulin)
GO:0007219 (Notch signaling pathway)
GO:0051000 (positive regulation of nitric-oxide synthase activity)
GO:0051712 (positive regulation of killing of cells of other organism)
GO:0051770 (positive regulation of nitric-oxide synthase biosynthetic process)
Wikipedia CD23

Target Cross References - Protein

canSAR P06734
Human Protein Atlas ENSG00000104921
IntAct P06734
Open Targets ENSG00000104921
PharmGKB PA28058
Reactome R-HSA-2197563 (NOTCH2 intracellular domain regulates transcription.)
R-HSA-6783783 (Interleukin-10 signaling.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
UniProt P06734

Target Cross References - Domain

InterPro IPR001304 (C-type_lectin-like.)
IPR016186 (C-type_lectin-like/link.)
IPR016187 (CTDL_fold.)
IPR018378 (C-type_lectin_CS.)
IPR033989 (CD209-like_CTLD.)
Pfam PF00059 (Lectin_C)

Target Cross References - Structure

PDBe 2H2R 2H2T 4EZM 4G96 4G9A 4GI0 4GJ0 4GJX 4GK1 4GKO 4J6J 4J6K 4J6L 4J6M 4J6N 4J6P 4J6Q 4KI1
CREDO 2H2R 2H2T 4EZM 4G96 4G9A 4GI0 4GJ0 4GJX 4GK1 4GKO 4J6J 4J6K 4J6L 4J6M 4J6N 4J6P 4J6Q 4KI1
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