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Target Report Card

Target Name and Classification

Target ID CHEMBL2937
Preferred Name Matrix metalloproteinase 17
Synonyms MMP-17 | MMP17 | MT-MMP 4 | MT4-MMP | MT4MMP | MT4MMP | MTMMP4 | Matrix metalloproteinase-17 | Membrane-type matrix metalloproteinase 4 | Membrane-type-4 matrix metalloproteinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m10a subfamily

Target Components

Component Description Relationship Accession
Matrix metalloproteinase-17 SINGLE PROTEIN Q9ULZ9

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198598
Ensembl ENSG00000198598
GO Cellular Component GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0031012 (extracellular matrix)
GO:0031225 (anchored component of membrane)
GO Molecular Function GO:0004222 (metalloendopeptidase activity)
GO:0005509 (calcium ion binding)
GO:0008047 (enzyme activator activity)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0043085 (positive regulation of catalytic activity)
Wikipedia MMP17

Target Cross References - Protein

Human Protein Atlas ENSG00000198598
Guide to Pharmacology 1641
Open Targets ENSG00000198598
PharmGKB PA30875
Reactome R-HSA-1592389 (Activation of Matrix Metalloproteinases.)
UniProt Q14850 Q9ULZ9

Target Cross References - Domain

InterPro IPR000585 (Hemopexin-like_dom.)
IPR001818 (Pept_M10_metallopeptidase.)
IPR002477 (Peptidoglycan-bd-like.)
IPR006026 (Peptidase_Metallo.)
IPR016293 (Pept_M10A_stromelysin-type.)
IPR018487 (Hemopexin-like_repeat.)
IPR021190 (Pept_M10A.)
IPR024079 (MetalloPept_cat_dom.)
IPR028726 (MMP17.)
Pfam PF00045 (Hemopexin)
PF00413 (Peptidase_M10)
PF01471 (PG_binding_1)