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Target Report Card

Target Name and Classification

Target ID CHEMBL2918
Target Type SINGLE PROTEIN
Preferred Name cAMP-dependent protein kinase beta-1 catalytic subunit
Synonyms PKA C-beta | PRKACB | cAMP-dependent protein kinase catalytic subunit beta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase pka family

Target Components

Component Description Relationship Accession
cAMP-dependent protein kinase catalytic subunit beta SINGLE PROTEIN P22694

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094138 cAMP-dependent protein kinase (PKA) PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000142875
Ensembl ENSG00000142875
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005952 (cAMP-dependent protein kinase complex)
GO:0016020 (membrane)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO:0097546 (ciliary base)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004691 (cAMP-dependent protein kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0031625 (ubiquitin protein ligase binding)
GO Biological Process GO:0001843 (neural tube closure)
GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0003091 (renal water homeostasis)
GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007596 (blood coagulation)
GO:0016310 (phosphorylation)
GO:0034199 (activation of protein kinase A activity)
GO:0042157 (lipoprotein metabolic process)
GO:0051447 (negative regulation of meiotic cell cycle)
GO:0070613 (regulation of protein processing)
GO:0071377 (cellular response to glucagon stimulus)
GO:0097338 (response to clozapine)
GO:1901621 (negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)
Wikipedia PRKACB

Target Cross References - Protein

canSAR P22694
Human Protein Atlas ENSG00000142875
IntAct P22694
Guide to Pharmacology 1477
Open Targets ENSG00000142875
PharmGKB PA33749
Pharos P22694 (Tchem)
Reactome R-HSA-111931 (PKA-mediated phosphorylation of CREB.)
R-HSA-163358 (PKA-mediated phosphorylation of key metabolic factors.)
R-HSA-163560 (Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.)
R-HSA-163615 (PKA activation.)
R-HSA-164378 (PKA activation in glucagon signalling.)
R-HSA-180024 (DARPP-32 events.)
R-HSA-194223 (HDL-mediated lipid transport.)
R-HSA-381676 (Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.)
R-HSA-392517 (Rap1 signalling.)
R-HSA-422356 (Regulation of insulin secretion.)
R-HSA-432040 (Vasopressin regulates renal water homeostasis via Aquaporins.)
R-HSA-4420097 (VEGFA-VEGFR2 Pathway.)
R-HSA-442720 (CREB phosphorylation through the activation of Adenylate Cyclase.)
R-HSA-5610780 (Degradation of GLI1 by the proteasome.)
R-HSA-5610783 (Degradation of GLI2 by the proteasome.)
R-HSA-5610785 (GLI3 is processed to GLI3R by the proteasome.)
R-HSA-5610787 (Hedgehog 'off' state.)
R-HSA-5621575 (CD209 (DC-SIGN) signaling.)
R-HSA-5687128 (MAPK6/MAPK4 signaling.)
R-HSA-70263 (Gluconeogenesis.)
R-HSA-983231 (Factors involved in megakaryocyte development and platelet production.)
UniProt B1APG4 B4DKB0 B4E2Q1 P22694 Q14VH1 Q59GC0 Q5BNE9 Q5BNF0 Q5BNF1 Q5BNF2 Q5BNF3 Q5CZ92 Q5T1K3 Q7Z3M1 Q8IYR5 Q8IZQ0 Q96B09

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)
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