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Target Report Card

Target Name and Classification

Target ID CHEMBL2916
Target Type SINGLE PROTEIN
Preferred Name Telomerase reverse transcriptase
Synonyms EST2 | HEST2 | TCS1 | TERT | TP2 | TRT | Telomerase catalytic subunit | Telomerase reverse transcriptase | Telomerase-associated protein 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Telomerase reverse transcriptase SINGLE PROTEIN O14746

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2107856 IMETELSTAT Telomerase reverse transcriptase inhibitor 3 PubMed PubMed
CHEMBL2108702 IMETELSTAT SODIUM Telomerase reverse transcriptase inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000164362
Ensembl ENSG00000164362
GO Cellular Component GO:0000333 (telomerase catalytic core complex)
GO:0000781 (chromosome, telomeric region)
GO:0000783 (nuclear telomere cap complex)
GO:0000784 (nuclear chromosome, telomeric region)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005694 (chromosome)
GO:0005697 (telomerase holoenzyme complex)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0016605 (PML body)
GO:0030529 (intracellular ribonucleoprotein complex)
GO:0031379 (RNA-directed RNA polymerase complex)
GO:0042645 (mitochondrial nucleoid)
GO:1990572 (TERT-RMRP complex)
GO Molecular Function GO:0000049 (tRNA binding)
GO:0001223 (transcription coactivator binding)
GO:0003677 (DNA binding)
GO:0003720 (telomerase activity)
GO:0003721 (telomerase RNA reverse transcriptase activity)
GO:0003723 (RNA binding)
GO:0003964 (RNA-directed DNA polymerase activity)
GO:0003968 (RNA-directed RNA polymerase activity)
GO:0005515 (protein binding)
GO:0016740 (transferase activity)
GO:0016779 (nucleotidyltransferase activity)
GO:0042162 (telomeric DNA binding)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO:0070034 (telomerase RNA binding)
GO Biological Process GO:0000723 (telomere maintenance)
GO:0001172 (transcription, RNA-templated)
GO:0006278 (RNA-dependent DNA biosynthetic process)
GO:0007004 (telomere maintenance via telomerase)
GO:0007005 (mitochondrion organization)
GO:0010629 (negative regulation of gene expression)
GO:0022616 (DNA strand elongation)
GO:0030177 (positive regulation of Wnt signaling pathway)
GO:0030422 (production of siRNA involved in RNA interference)
GO:0031647 (regulation of protein stability)
GO:0032092 (positive regulation of protein binding)
GO:0032774 (RNA biosynthetic process)
GO:0042635 (positive regulation of hair cycle)
GO:0051000 (positive regulation of nitric-oxide synthase activity)
GO:0070200 (establishment of protein localization to telomere)
GO:0071456 (cellular response to hypoxia)
GO:0071897 (DNA biosynthetic process)
GO:0090399 (replicative senescence)
GO:1902895 (positive regulation of pri-miRNA transcription from RNA polymerase II promoter)
GO:1903704 (negative regulation of production of siRNA involved in RNA interference)
GO:1904751 (positive regulation of protein localization to nucleolus)
GO:1904837 (beta-catenin-TCF complex assembly)
GO:2000648 (positive regulation of stem cell proliferation)
GO:2000773 (negative regulation of cellular senescence)
GO:2001240 (negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)
Wikipedia Telomerase_reverse_transcriptase

Target Cross References - Protein

canSAR O14746
CGD Aplastic anemia; Dyskeratosis congenita, autosomal dominant; Dyskeratosis congenita, autosomal recessive; Pulmonary fibrosis and/or bone marrow failure, telomere-related 1
Human Protein Atlas ENSG00000164362
IntAct O14746
Open Targets ENSG00000164362
PharmGKB PA36447
Reactome R-HSA-171319 (Telomere Extension By Telomerase.)
R-HSA-201722 (Formation of the beta-catenin:TCF transactivating complex.)
UniProt O14746 O14783 Q2XS35 Q8N6C3 Q8NG38 Q8NG46

Target Cross References - Domain

InterPro IPR000477 (RT_dom.)
IPR003545 (Telomerase_RT.)
IPR021891 (Telomerase_RBD.)
Pfam PF00078 (RVT_1)
PF12009 (Telomerase_RBD)

Target Cross References - Structure

PDBe 2BCK 4B18 4MNQ 5MEN 5MEP 5MEQ 5MER
CREDO 2BCK 4B18 4MNQ 5MEN 5MEP 5MEQ 5MER
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