ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL2911
Target Type SINGLE PROTEIN
Preferred Name Phosphoenolpyruvate carboxykinase cytosolic
Synonyms PCK1 | PEPCK-C | PEPCK1 | Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Phosphoenolpyruvate carboxykinase, cytosolic [GTP] SINGLE PROTEIN P35558

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000124253
Ensembl ENSG00000124253
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004611 (phosphoenolpyruvate carboxykinase activity)
GO:0004613 (phosphoenolpyruvate carboxykinase (GTP) activity)
GO:0005525 (GTP binding)
GO:0016829 (lyase activity)
GO:0016831 (carboxy-lyase activity)
GO:0017076 (purine nucleotide binding)
GO:0019003 (GDP binding)
GO:0030145 (manganese ion binding)
GO:0031406 (carboxylic acid binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006006 (glucose metabolic process)
GO:0006094 (gluconeogenesis)
GO:0006107 (oxaloacetate metabolic process)
GO:0006475 (internal protein amino acid acetylation)
GO:0006629 (lipid metabolic process)
GO:0014823 (response to activity)
GO:0032868 (response to insulin)
GO:0042593 (glucose homeostasis)
GO:0046327 (glycerol biosynthetic process from pyruvate)
GO:0051365 (cellular response to potassium ion starvation)
GO:0061402 (positive regulation of transcription from RNA polymerase II promoter in response to acidic pH)
Wikipedia PCK1

Target Cross References - Protein

canSAR P35558
Human Protein Atlas ENSG00000124253
IntAct P35558
Open Targets ENSG00000124253
PharmGKB PA33069
Reactome R-HSA-2161541 (Abacavir metabolism.)
R-HSA-381340 (Transcriptional regulation of white adipocyte differentiation.)
R-HSA-70263 (Gluconeogenesis.)
UniProt A8K437 B4DT64 P35558 Q8TCA3 Q9UJD2

Target Cross References - Domain

InterPro IPR008209 (PEP_carboxykinase_GTP.)
IPR008210 (PEP_carboxykinase_N.)
IPR013035 (PEP_carboxykinase_C.)
IPR018091 (PEP_carboxykin_GTP_CS.)
Pfam PF00821 (PEPCK)

Target Cross References - Structure

PDBe 1KHB 1KHE 1KHF 1KHG 1M51 1NHX 2GMV
CREDO 1KHB 1KHE 1KHF 1KHG 1M51 1NHX 2GMV
spacer
spacer