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Target Report Card

Target Name and Classification

Target ID CHEMBL2898
Preferred Name NF-kappaB inhibitor alpha
Synonyms I-kappa-B-alpha | IKBA | IkB-alpha | IkappaBalpha | MAD3 | Major histocompatibility complex enhancer-binding protein MAD3 | NF-kappa-B inhibitor alpha | NFKBI | NFKBIA
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
NF-kappa-B inhibitor alpha SINGLE PROTEIN P25963

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100906
Ensembl ENSG00000100906
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0033256 (I-kappaB/NF-kappaB complex)
GO:0043234 (protein complex)
GO Molecular Function GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0008139 (nuclear localization sequence binding)
GO:0019899 (enzyme binding)
GO:0031072 (heat shock protein binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0032403 (protein complex binding)
GO:0042802 (identical protein binding)
GO:0051059 (NF-kappaB binding)
GO Biological Process GO:0000060 (protein import into nucleus, translocation)
GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0006915 (apoptotic process)
GO:0007253 (cytoplasmic sequestering of NF-kappaB)
GO:0010468 (regulation of gene expression)
GO:0010745 (negative regulation of macrophage derived foam cell differentiation)
GO:0010875 (positive regulation of cholesterol efflux)
GO:0010888 (negative regulation of lipid storage)
GO:0016032 (viral process)
GO:0031663 (lipopolysaccharide-mediated signaling pathway)
GO:0032088 (negative regulation of NF-kappaB transcription factor activity)
GO:0032270 (positive regulation of cellular protein metabolic process)
GO:0032495 (response to muramyl dipeptide)
GO:0032496 (response to lipopolysaccharide)
GO:0034142 (toll-like receptor 4 signaling pathway)
GO:0035994 (response to muscle stretch)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0042127 (regulation of cell proliferation)
GO:0042345 (regulation of NF-kappaB import into nucleus)
GO:0042994 (cytoplasmic sequestering of transcription factor)
GO:0043066 (negative regulation of apoptotic process)
GO:0043330 (response to exogenous dsRNA)
GO:0043392 (negative regulation of DNA binding)
GO:0045638 (negative regulation of myeloid cell differentiation)
GO:0045746 (negative regulation of Notch signaling pathway)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0050852 (T cell receptor signaling pathway)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0070417 (cellular response to cold)
GO:0070427 (nucleotide-binding oligomerization domain containing 1 signaling pathway)
GO:0070431 (nucleotide-binding oligomerization domain containing 2 signaling pathway)
GO:0071345 (cellular response to cytokine stimulus)
GO:0071407 (cellular response to organic cyclic compound)
Wikipedia I%CE%BAB%CE%B1

Target Cross References - Protein

canSAR P25963
CGD Ectodermal dysplasia, anhidrotic, with T-cell immunodeficiency
Human Protein Atlas ENSG00000100906
IntAct P25963
Open Targets ENSG00000100906
PharmGKB PA31601
Reactome R-HSA-1169091 (Activation of NF-kappaB in B cells.)
R-HSA-1810476 (RIP-mediated NFkB activation via ZBP1.)
R-HSA-202424 (Downstream TCR signaling.)
R-HSA-209560 (NF-kB is activated and signals survival.)
R-HSA-2871837 (FCERI mediated NF-kB activation.)
R-HSA-445989 (TAK1 activates NFkB by phosphorylation and activation of IKKs complex.)
R-HSA-5603027 (IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR).)
R-HSA-5603029 (IkBA variant leads to EDA-ID.)
R-HSA-5607764 (CLEC7A (Dectin-1) signaling.)
R-HSA-933542 (TRAF6 mediated NF-kB activation.)
UniProt B2R8L6 P25963

Target Cross References - Domain

InterPro IPR002110 (Ankyrin_rpt.)
IPR020683 (Ankyrin_rpt-contain_dom.)
Pfam PF00023 (Ank)
PF12796 (Ank_2)

Target Cross References - Structure