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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2897
Target Type SINGLE PROTEIN
Preferred Name Dual specificity mitogen-activated protein kinase kinase 4
Synonyms Dual specificity mitogen-activated protein kinase kinase 4 | JNK-activating kinase 1 | JNKK | JNKK1 | MAP kinase kinase 4 | MAP2K4 | MAPK/ERK kinase 4 | MAPKK 4 | MEK 4 | MEK4 | MKK4 | PRKMK4 | SAPK kinase 1 | SAPK/ERK kinase 1 | SAPKK-1 | SAPKK1 | SEK1 | SEK1 | SERK1 | SKK1 | Stress-activated protein kinase kinase 1 | c-Jun N-terminal kinase kinase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste7 family

Target Components

Component Description Relationship Accession
Dual specificity mitogen-activated protein kinase kinase 4 SINGLE PROTEIN P45985

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000065559
Ensembl ENSG00000065559
GO Cellular Component GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005829 (cytosol)
GO Molecular Function GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008545 (JUN kinase kinase activity)
GO Biological Process GO:0002224 (toll-like receptor signaling pathway)
GO:0002755 (MyD88-dependent toll-like receptor signaling pathway)
GO:0002756 (MyD88-independent toll-like receptor signaling pathway)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007165 (signal transduction)
GO:0007254 (JNK cascade)
GO:0007257 (activation of JUN kinase activity)
GO:0008063 (Toll signaling pathway)
GO:0034130 (toll-like receptor 1 signaling pathway)
GO:0034134 (toll-like receptor 2 signaling pathway)
GO:0034138 (toll-like receptor 3 signaling pathway)
GO:0034142 (toll-like receptor 4 signaling pathway)
GO:0034146 (toll-like receptor 5 signaling pathway)
GO:0034162 (toll-like receptor 9 signaling pathway)
GO:0034166 (toll-like receptor 10 signaling pathway)
GO:0035666 (TRIF-dependent toll-like receptor signaling pathway)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0038123 (toll-like receptor TLR1:TLR2 signaling pathway)
GO:0038124 (toll-like receptor TLR6:TLR2 signaling pathway)
GO:0045087 (innate immune response)
GO:0051403 (stress-activated MAPK cascade)
GO:0071260 (cellular response to mechanical stimulus)
Wikipedia MAP2K4

Target Cross References - Protein

canSAR P45985
Human Protein Atlas ENSG00000065559
IntAct P45985
PharmGKB PA30589
UniProt B2R7N7 B3KYB2 D3DTS5 P45985 Q5U0B8 Q6FHX4 Q6P9H2 Q6PIE6

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR000719 (Prot_kinase_dom.)
IPR002290 (Ser/Thr_dual-sp_kinase.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 3ALN 3ALO 3VUT
CREDO 3ALN 3ALO 3VUT
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