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Target Report Card

Target Name and Classification

Target ID CHEMBL2889
Target Type SINGLE PROTEIN
Preferred Name Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
Synonyms Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP | LyP | Lymphoid phosphatase | PEP | PEST-domain phosphatase | PTPN22 | PTPN8 | Tyrosine-protein phosphatase non-receptor type 22
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphatase > protein phosphatase > tyrosine protein phosphatase

Target Components

Component Description Relationship Accession
Tyrosine-protein phosphatase non-receptor type 22 SINGLE PROTEIN Q9Y2R2

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000134242
Ensembl ENSG00000134242
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0009898 (cytoplasmic side of plasma membrane)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0004721 (phosphoprotein phosphatase activity)
GO:0004725 (protein tyrosine phosphatase activity)
GO:0005515 (protein binding)
GO:0016787 (hydrolase activity)
GO:0016791 (phosphatase activity)
GO:0017124 (SH3 domain binding)
GO:0019900 (kinase binding)
GO:0031625 (ubiquitin protein ligase binding)
GO Biological Process GO:0002376 (immune system process)
GO:0006470 (protein dephosphorylation)
GO:0006914 (autophagy)
GO:0010507 (negative regulation of autophagy)
GO:0010628 (positive regulation of gene expression)
GO:0010629 (negative regulation of gene expression)
GO:0016311 (dephosphorylation)
GO:0030217 (T cell differentiation)
GO:0031663 (lipopolysaccharide-mediated signaling pathway)
GO:0032481 (positive regulation of type I interferon production)
GO:0032496 (response to lipopolysaccharide)
GO:0032720 (negative regulation of tumor necrosis factor production)
GO:0032817 (regulation of natural killer cell proliferation)
GO:0034141 (positive regulation of toll-like receptor 3 signaling pathway)
GO:0034145 (positive regulation of toll-like receptor 4 signaling pathway)
GO:0035335 (peptidyl-tyrosine dephosphorylation)
GO:0035644 (phosphoanandamide dephosphorylation)
GO:0043508 (negative regulation of JUN kinase activity)
GO:0045088 (regulation of innate immune response)
GO:0050855 (regulation of B cell receptor signaling pathway)
GO:0050856 (regulation of T cell receptor signaling pathway)
GO:0050860 (negative regulation of T cell receptor signaling pathway)
GO:0050868 (negative regulation of T cell activation)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0070433 (negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)
GO:0071225 (cellular response to muramyl dipeptide)
GO:1900165 (negative regulation of interleukin-6 secretion)
GO:1901222 (regulation of NIK/NF-kappaB signaling)
GO:1902523 (positive regulation of protein K63-linked ubiquitination)
GO:1902715 (positive regulation of interferon-gamma secretion)
GO:1903753 (negative regulation of p38MAPK cascade)
GO:2000483 (negative regulation of interleukin-8 secretion)
Wikipedia PTPN22

Target Cross References - Protein

canSAR Q9Y2R2
Human Protein Atlas ENSG00000134242
IntAct Q9Y2R2
Open Targets ENSG00000134242
PharmGKB PA33995
Reactome R-HSA-202427 (Phosphorylation of CD3 and TCR zeta chains.)
R-HSA-202430 (Translocation of ZAP-70 to Immunological synapse.)
UniProt A0N0K6 B1ALC8 D4NZ71 E9PLD8 E9PPI1 O95063 O95064 Q6IPX8 Q8WVM1 Q9Y2R2

Target Cross References - Domain

InterPro IPR000242 (PTPase_domain.)
IPR000387 (TYR_PHOSPHATASE_dom.)
IPR003595 (Tyr_Pase_cat.)
IPR016130 (Tyr_Pase_AS.)
IPR016276 (PTPN22.)
IPR029021 (Prot-tyrosine_phosphatase-like.)
Pfam PF00102 (Y_phosphatase)

Target Cross References - Structure

PDBe 2P6X 2QCJ 2QCT 3BRH 3H2X 3OLR 3OMH 4J51
CREDO 2P6X 2QCJ 2QCT 3BRH 3H2X 3OLR 3OMH 4J51
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