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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2887
Preferred Name Hemoglobin alpha subunit
Synonyms Alpha-globin | HBA2 | Hemoglobin alpha chain | Hemoglobin subunit alpha | and
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Hemoglobin subunit alpha SINGLE PROTEIN P69905

Target Relations

ChEMBL ID Pref Name Target Type

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000188536 ENSG00000206172
Ensembl ENSG00000188536 ENSG00000206172
GO Cellular Component GO:0005576 (extracellular region)
GO:0005829 (cytosol)
GO:0005833 (hemoglobin complex)
GO:0016020 (membrane)
GO:0022627 (cytosolic small ribosomal subunit)
GO:0031838 (haptoglobin-hemoglobin complex)
GO:0070062 (extracellular exosome)
GO:0071682 (endocytic vesicle lumen)
GO:0072562 (blood microparticle)
GO Molecular Function GO:0004601 (peroxidase activity)
GO:0005344 (oxygen transporter activity)
GO:0005506 (iron ion binding)
GO:0005515 (protein binding)
GO:0019825 (oxygen binding)
GO:0020037 (heme binding)
GO:0031720 (haptoglobin binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006810 (transport)
GO:0006898 (receptor-mediated endocytosis)
GO:0010942 (positive regulation of cell death)
GO:0015671 (oxygen transport)
GO:0015701 (bicarbonate transport)
GO:0042542 (response to hydrogen peroxide)
GO:0042744 (hydrogen peroxide catabolic process)
GO:0051291 (protein heterooligomerization)
GO:0098869 (cellular oxidant detoxification)
Wikipedia Hemoglobin,_alpha_1

Target Cross References - Protein

canSAR P69905
CGD Alpha thalassemia
Human Protein Atlas ENSG00000188536 ENSG00000206172
IntAct P69905
Open Targets ENSG00000188536 ENSG00000206172
PharmGKB PA29199
Reactome R-HSA-1237044 (Erythrocytes take up carbon dioxide and release oxygen.)
R-HSA-1247673 (Erythrocytes take up oxygen and release carbon dioxide.)
R-HSA-2168880 (Scavenging of heme from plasma.)
UniProt P01922 P69905 Q1HDT5 Q3MIF5 Q53F97 Q96KF1 Q9NYR7 Q9UCM0

Target Cross References - Domain

InterPro IPR000971 (Globin.)
IPR002338 (Haemoglobin_a-typ.)
IPR002339 (Haemoglobin_pi.)
IPR009050 (Globin-like.)
IPR012292 (Globin/Proto.)
Pfam PF00042 (Globin)

Target Cross References - Structure

PDBe 1A00 1A01 1A0U 1A0Z 1A3N 1A3O 1A9W 1ABW 1ABY 1AJ9 1B86 1BAB 1BBB 1BIJ 1BUW 1BZ0 1BZ1 1BZZ 1C7B 1C7C 1C7D 1CLS 1CMY 1COH More...
CREDO 1A00 1A01 1A0U 1A0Z 1A3N 1A3O 1A9W 1ABW 1ABY 1AJ9 1B86 1BAB 1BBB 1BIJ 1BUW 1BZ0 1BZ1 1BZZ 1C7B 1C7C 1C7D 1CLS 1CMY 1COH More...