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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2886
Target Type SINGLE PROTEIN
Preferred Name Phosphoglycerate kinase 1
Synonyms Cell migration-inducing gene 10 protein | OK/SW-cl.110 | PGK1 | PGKA | PRP 2 | Phosphoglycerate kinase 1 | Primer recognition protein 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Phosphoglycerate kinase 1 SINGLE PROTEIN P00558

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096677 Phosphoglycerate kinase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000102144
Ensembl ENSG00000102144
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0045121 (membrane raft)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004618 (phosphoglycerate kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006094 (gluconeogenesis)
GO:0006096 (glycolytic process)
GO:0016310 (phosphorylation)
GO:0030855 (epithelial cell differentiation)
GO:0061621 (canonical glycolysis)
Wikipedia PGK1

Target Cross References - Protein

canSAR P00558
CGD Phosphoglycerate kinase 1 deficiency
Human Protein Atlas ENSG00000102144
IntAct P00558
Open Targets ENSG00000102144
PharmGKB PA33234
Pharos P00558 (Tbio)
Reactome R-HSA-70171 (Glycolysis.)
R-HSA-70263 (Gluconeogenesis.)
UniProt A8K4W6 B7Z7A9 P00558 Q5J7W1 Q6IBT6 Q8NI87

Target Cross References - Domain

InterPro IPR001576 (Phosphoglycerate_kinase.)
IPR015824 (Phosphoglycerate_kinase_N.)
IPR015901 (Phosphoglycerate_kinase_C.)
IPR015911 (Phosphoglycerate_kinase_CS.)
Pfam PF00162 (PGK)

Target Cross References - Structure

PDBe 2WZB 2WZC 2WZD 2X13 2X14 2X15 2XE6 2XE7 2XE8 2Y3I 2YBE 2ZGV 3C39 3C3A 3C3B 3C3C 3ZOZ 4AXX 4O33
CREDO 2WZB 2WZC 2WZD 2X13 2X14 2X15 2XE6 2XE7 2XE8 2Y3I 2YBE 2ZGV 3C39 3C3A 3C3B 3C3C 3ZOZ 4AXX 4O33
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