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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2885
Target Type SINGLE PROTEIN
Preferred Name Carbonic anhydrase III
Synonyms CA-III | CA3 | Carbonate dehydratase III | Carbonic anhydrase 3 | Carbonic anhydrase III
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > lyase

Target Components

Component Description Relationship Accession
Carbonic anhydrase 3 SINGLE PROTEIN P07451

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095180 Carbonic anhydrase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000164879
Ensembl ENSG00000164879
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0004089 (carbonate dehydratase activity)
GO:0008270 (zinc ion binding)
GO:0016151 (nickel cation binding)
GO:0016791 (phosphatase activity)
GO:0016829 (lyase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006730 (one-carbon metabolic process)
GO:0006979 (response to oxidative stress)
GO:0015701 (bicarbonate transport)
GO:0016311 (dephosphorylation)
GO:0045471 (response to ethanol)
Wikipedia Carbonic_anhydrase_III,_muscle_specific

Target Cross References - Protein

canSAR P07451
Human Protein Atlas ENSG00000164879
IntAct P07451
Open Targets ENSG00000164879
PharmGKB PA25990
Reactome R-HSA-1475029 (Reversible hydration of carbon dioxide.)
UniProt B2R867 B3KUC8 O60842 P07451

Target Cross References - Domain

InterPro IPR001148 (Carbonic_anhydrase_a.)
IPR018338 (Carbonic_anhydrase_a-class_CS.)
IPR018441 (Carbonic_anhydrase_CA3.)
IPR023561 (Carbonic_anhydrase_a-class.)
Pfam PF00194 (Carb_anhydrase)

Target Cross References - Structure

PDBe 1Z93 1Z97 2HFW 3UYN 3UYQ
CREDO 1Z93 1Z97 2HFW 3UYN 3UYQ
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