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Target Report Card

Target Name and Classification

Target ID CHEMBL2883
Target Type SINGLE PROTEIN
Preferred Name Thymidine kinase, cytosolic
Synonyms TK1 | Thymidine kinase, cytosolic
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Thymidine kinase, cytosolic SINGLE PROTEIN P04183

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000167900
Ensembl ENSG00000167900
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004797 (thymidine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008270 (zinc ion binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019206 (nucleoside kinase activity)
GO:0042802 (identical protein binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001889 (liver development)
GO:0006139 (nucleobase-containing compound metabolic process)
GO:0006259 (DNA metabolic process)
GO:0009157 (deoxyribonucleoside monophosphate biosynthetic process)
GO:0009165 (nucleotide biosynthetic process)
GO:0009636 (response to toxic substance)
GO:0014856 (skeletal muscle cell proliferation)
GO:0016310 (phosphorylation)
GO:0031667 (response to nutrient levels)
GO:0043097 (pyrimidine nucleoside salvage)
GO:0046104 (thymidine metabolic process)
GO:0046688 (response to copper ion)
GO:0048565 (digestive tract development)
GO:0051289 (protein homotetramerization)
GO:0051414 (response to cortisol)
GO:0060138 (fetal process involved in parturition)
GO:0071897 (DNA biosynthetic process)
Wikipedia Thymidine_kinase_1

Target Cross References - Protein

canSAR P04183
Human Protein Atlas ENSG00000167900
IntAct P04183
MICAD NBK23373 (Thymidine kinase-1)
Open Targets ENSG00000167900
PharmGKB PA352
Pharos P04183 (Tchem)
Reactome R-HSA-73614 (Pyrimidine salvage reactions.)
UniProt B2RC58 P04183 Q969V0 Q9UMG9

Target Cross References - Domain

InterPro IPR001267 (Thymidine_kinase.)
IPR020633 (Thymidine_kinase_CS.)
IPR027417 (P-loop_NTPase.)
Pfam PF00265 (TK)

Target Cross References - Structure

PDBe 1W4R 1XBT 2ORV 2WVJ
CREDO 1W4R 1XBT 2ORV 2WVJ
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