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Target Report Card

Target Name and Classification

Target ID CHEMBL288
Preferred Name Phosphodiesterase 4D
Synonyms DPDE3 | DPDE3 | PDE43 | PDE4D | cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphodiesterase > phosphodiesterase 4 > phosphodiesterase 4d

Target Components

Component Description Relationship Accession
cAMP-specific 3',5'-cyclic phosphodiesterase 4D SINGLE PROTEIN Q08499

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363066 3',5'-cyclic phosphodiesterase PROTEIN FAMILY
CHEMBL2095153 Phosphodiesterase; PDE3 & PDE4 SELECTIVITY GROUP
CHEMBL2093863 Phosphodiesterase 4 PROTEIN FAMILY
CHEMBL2111340 Phosphodiesterase 4 and 5 (PDE4 and PDE5) SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000113448
Ensembl ENSG00000113448
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0005815 (microtubule organizing center)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005886 (plasma membrane)
GO:0005891 (voltage-gated calcium channel complex)
GO:0016020 (membrane)
GO:0016324 (apical plasma membrane)
GO:0031965 (nuclear membrane)
GO:0034704 (calcium channel complex)
GO Molecular Function GO:0004114 (3',5'-cyclic-nucleotide phosphodiesterase activity)
GO:0004115 (3',5'-cyclic-AMP phosphodiesterase activity)
GO:0005515 (protein binding)
GO:0008081 (phosphoric diester hydrolase activity)
GO:0008144 (drug binding)
GO:0016787 (hydrolase activity)
GO:0019899 (enzyme binding)
GO:0030552 (cAMP binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0031698 (beta-2 adrenergic receptor binding)
GO:0044325 (ion channel binding)
GO:0046872 (metal ion binding)
GO:0051117 (ATPase binding)
GO:0097110 (scaffold protein binding)
GO Biological Process GO:0002027 (regulation of heart rate)
GO:0006198 (cAMP catabolic process)
GO:0006939 (smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007568 (aging)
GO:0010469 (regulation of receptor activity)
GO:0010880 (regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)
GO:0019933 (cAMP-mediated signaling)
GO:0030593 (neutrophil chemotaxis)
GO:0030814 (regulation of cAMP metabolic process)
GO:0032729 (positive regulation of interferon-gamma production)
GO:0032743 (positive regulation of interleukin-2 production)
GO:0032754 (positive regulation of interleukin-5 production)
GO:0033137 (negative regulation of peptidyl-serine phosphorylation)
GO:0035264 (multicellular organism growth)
GO:0045822 (negative regulation of heart contraction)
GO:0050852 (T cell receptor signaling pathway)
GO:0050900 (leukocyte migration)
GO:0060314 (regulation of ryanodine-sensitive calcium-release channel activity)
GO:0061028 (establishment of endothelial barrier)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071320 (cellular response to cAMP)
GO:0071872 (cellular response to epinephrine stimulus)
GO:0071875 (adrenergic receptor signaling pathway)
GO:0086004 (regulation of cardiac muscle cell contraction)
GO:0086024 (adrenergic receptor signaling pathway involved in positive regulation of heart rate)
GO:1901844 (regulation of cell communication by electrical coupling involved in cardiac conduction)
GO:1901898 (negative regulation of relaxation of cardiac muscle)
Wikipedia PDE4D

Target Cross References - Protein

canSAR Q08499
CGD Acrodysostosis 2, with or without hormone resistance
Human Protein Atlas ENSG00000113448
IntAct Q08499
Guide to Pharmacology 1303
Open Targets ENSG00000113448
PharmGKB PA33130
Reactome R-HSA-180024 (DARPP-32 events.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt O43433 Q08499 Q13549 Q13550 Q13551 Q7Z2L8 Q8IV84 Q8IVA9 Q8IVD2 Q8IVD3 Q96HL4 Q9HCX7

Target Cross References - Domain

InterPro IPR002073 (PDEase_catalytic_dom.)
IPR003607 (HD/PDEase_dom.)
IPR023088 (PDEase.)
IPR023174 (PDEase_CS.)
IPR036971 (PDEase_catalytic_dom_sf.)
Pfam PF00233 (PDEase_I)

Target Cross References - Structure

PDBe 1MKD 1OYN 1PTW 1Q9M 1TB7 1TBB 1XOM 1XON 1XOQ 1XOR 1Y2B 1Y2C 1Y2D 1Y2E 1Y2K 1ZKN 2FM0 2FM5 2PW3 2QYN 3G4G 3G4I 3G4K 3G4L More...
CREDO 1MKD 1OYN 1PTW 1Q9M 1TB7 1TBB 1XOM 1XON 1XOQ 1XOR 1Y2B 1Y2C 1Y2D 1Y2E 1Y2K 1ZKN 2FM0 2FM5 2PW3 2QYN 3G4G 3G4I 3G4K 3G4L More...