ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL2867
Preferred Name Matrix metalloproteinase 11
Synonyms MMP-11 | MMP11 | Matrix metalloproteinase-11 | SL-3 | ST3 | STMY3 | Stromelysin-3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m10a subfamily

Target Components

Component Description Relationship Accession
Stromelysin-3 SINGLE PROTEIN P24347

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000099953 ENSG00000275365
Ensembl ENSG00000099953 ENSG00000275365
GO Cellular Component GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0005796 (Golgi lumen)
GO:0031012 (extracellular matrix)
GO Molecular Function GO:0004222 (metalloendopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0007275 (multicellular organism development)
GO:0022617 (extracellular matrix disassembly)
GO:0030198 (extracellular matrix organization)
GO:0030199 (collagen fibril organization)
GO:0030574 (collagen catabolic process)
GO:0045599 (negative regulation of fat cell differentiation)
GO:0071711 (basement membrane organization)
Wikipedia MMP11

Target Cross References - Protein

Human Protein Atlas ENSG00000099953 ENSG00000275365
Guide to Pharmacology 1635
Open Targets ENSG00000099953 ENSG00000275365
PharmGKB PA30869
Reactome R-HSA-1442490 (Collagen degradation.)
R-HSA-1474228 (Degradation of the extracellular matrix.)
R-HSA-1592389 (Activation of Matrix Metalloproteinases.)
UniProt P24347 Q5FX24 Q6PEZ6 Q9UC26

Target Cross References - Domain

InterPro IPR000585 (Hemopexin-like_dom.)
IPR001818 (Pept_M10_metallopeptidase.)
IPR006026 (Peptidase_Metallo.)
IPR018486 (Hemopexin_CS.)
IPR018487 (Hemopexin-like_repeat.)
IPR021158 (Pept_M10A_Zn_BS.)
IPR021190 (Pept_M10A.)
IPR024079 (MetalloPept_cat_dom_sf.)
IPR028705 (Stromelysin-3.)
IPR033739 (M10A_MMP.)
IPR036375 (Hemopexin-like_dom_sf.)
Pfam PF00045 (Hemopexin)
PF00413 (Peptidase_M10)