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Target Report Card

Target Name and Classification

Target ID CHEMBL2862
Preferred Name Rho/Rac guanine nucleotide exchange factor
Synonyms FGD1 | FGDY | FYVE, RhoGEF and PH domain-containing protein 1 | Faciogenital dysplasia 1 protein | Rho/Rac GEF | Rho/Rac guanine nucleotide exchange factor FGD1 | ZFYVE3 | Zinc finger FYVE domain-containing protein 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
FYVE, RhoGEF and PH domain-containing protein 1 SINGLE PROTEIN P98174

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000102302
Ensembl ENSG00000102302
GO Cellular Component GO:0001726 (ruffle)
GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0030027 (lamellipodium)
GO:0042995 (cell projection)
GO Molecular Function GO:0005085 (guanyl-nucleotide exchange factor activity)
GO:0005089 (Rho guanyl-nucleotide exchange factor activity)
GO:0031267 (small GTPase binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0007010 (cytoskeleton organization)
GO:0007165 (signal transduction)
GO:0007275 (multicellular organism development)
GO:0008360 (regulation of cell shape)
GO:0009887 (organ morphogenesis)
GO:0030036 (actin cytoskeleton organization)
GO:0035023 (regulation of Rho protein signal transduction)
GO:0043065 (positive regulation of apoptotic process)
GO:0043087 (regulation of GTPase activity)
GO:0043547 (positive regulation of GTPase activity)
GO:0046847 (filopodium assembly)
GO:0051056 (regulation of small GTPase mediated signal transduction)
Wikipedia FGD1

Target Cross References - Protein

canSAR P98174
CGD Aarskog-Scott syndrome; Mental retardation, X-linked syndromic 16
Human Protein Atlas ENSG00000102302
IntAct P98174
Open Targets ENSG00000102302
PharmGKB PA28102
Reactome R-HSA-193648 (NRAGE signals death through JNK.)
R-HSA-194840 (Rho GTPase cycle.)
R-HSA-416482 (G alpha (12/13) signalling events.)
UniProt P98174 Q5H999 Q8N4D9

Target Cross References - Domain

InterPro IPR000219 (DH-domain.)
IPR000306 (Znf_FYVE.)
IPR001849 (PH_domain.)
IPR011993 (PH_dom-like.)
IPR013083 (Znf_RING/FYVE/PHD.)
IPR017455 (Znf_FYVE-rel.)
Pfam PF00169 (PH)
PF00621 (RhoGEF)
PF01363 (FYVE)