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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2845
Target Type SINGLE PROTEIN
Preferred Name Protein phosphatase 2C beta
Synonyms PP2C-beta | PP2CB | PPM1B | Protein phosphatase 1B | Protein phosphatase 2C isoform beta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphatase > protein phosphatase > serine/threonine protein phosphatase

Target Components

Component Description Relationship Accession
Protein phosphatase 1B SINGLE PROTEIN O75688

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000138032
Ensembl ENSG00000138032
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0003824 (catalytic activity)
GO:0004721 (phosphoprotein phosphatase activity)
GO:0004722 (protein serine/threonine phosphatase activity)
GO:0005515 (protein binding)
GO:0016787 (hydrolase activity)
GO:0030145 (manganese ion binding)
GO:0043169 (cation binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006470 (protein dephosphorylation)
GO:0006499 (N-terminal protein myristoylation)
GO:0032688 (negative regulation of interferon-beta production)
GO:0035970 (peptidyl-threonine dephosphorylation)
GO:0042347 (negative regulation of NF-kappaB import into nucleus)
GO:0043124 (negative regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0050687 (negative regulation of defense response to virus)
Wikipedia PPM1B

Target Cross References - Protein

canSAR O75688
Human Protein Atlas ENSG00000138032
IntAct O75688
Open Targets ENSG00000138032
PharmGKB PA33604
Reactome R-HSA-1169408 (ISG15 antiviral mechanism.)
UniProt O75688 Q461Q2 Q4J6C1 Q4J6C2 Q658R4 Q96ER6 Q9HAY8

Target Cross References - Domain

InterPro IPR000222 (PP2C_BS.)
IPR001932 (PPM-type_phosphatase_dom.)
IPR012911 (PP2C_C.)
IPR015655 (PP2C.)
Pfam PF00481 (PP2C)
PF07830 (PP2C_C)

Target Cross References - Structure

PDBe 2P8E
CREDO 2P8E
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