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Target Report Card

Target Name and Classification

Target ID CHEMBL2842
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase mTOR
Synonyms FK506-binding protein 12-rapamycin complex-associated protein 1 | FKBP12-rapamycin complex-associated protein | FRAP | FRAP1 | FRAP2 | MTOR | Mammalian target of rapamycin | Mechanistic target of rapamycin | RAFT1 | RAPT1 | Rapamycin and FKBP12 target 1 | Rapamycin target protein 1 | Serine/threonine-protein kinase mTOR | mTOR
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase mTOR SINGLE PROTEIN P42345

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2221341 Mammalian target of Rapamycin (mTORC1) PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2103839 RIDAFOROLIMUS Serine/threonine-protein kinase mTOR inhibitor 3 PubMed
CHEMBL592445 GEDATOLISIB Serine/threonine-protein kinase mTOR inhibitor 2 PubMed PubMed
CHEMBL1078983 AZD-2014 Serine/threonine-protein kinase mTOR inhibitor 2 Other PubMed
CHEMBL1234354 PF-04691502 Serine/threonine-protein kinase mTOR inhibitor 2 PubMed PubMed
CHEMBL1879463 DACTOLISIB Serine/threonine-protein kinase mTOR inhibitor 2 PubMed PubMed
CHEMBL1922094 APITOLISIB Serine/threonine-protein kinase mTOR inhibitor 2 PubMed PubMed
CHEMBL2326966 SF-1126 Serine/threonine-protein kinase mTOR inhibitor 2 ClinicalTrials PubMed
CHEMBL3120215 OSI-027 Serine/threonine-protein kinase mTOR inhibitor 2 PubMed
CHEMBL3544999 LY-3023414 Serine/threonine-protein kinase mTOR inhibitor 2 Other
CHEMBL3545096 BGT-226 Serine/threonine-protein kinase mTOR inhibitor 2 PubMed PubMed
CHEMBL3545097 MLN-0128 Serine/threonine-protein kinase mTOR inhibitor 2 PubMed PubMed
CHEMBL3545151 CC-223 Serine/threonine-protein kinase mTOR inhibitor 2 PubMed
CHEMBL3545366 VOXTALISIB Serine/threonine-protein kinase mTOR inhibitor 2 Other PubMed PubMed
CHEMBL1079593 VS-5584 Serine/threonine-protein kinase mTOR inhibitor 1 PubMed
CHEMBL1236962 OMIPALISIB Serine/threonine-protein kinase mTOR inhibitor 1 PubMed PubMed
CHEMBL1258517 PKI-179 Serine/threonine-protein kinase mTOR inhibitor 1 PubMed
CHEMBL1801204 AZD-8055 Serine/threonine-protein kinase mTOR inhibitor 1 PubMed
CHEMBL2141712 Palomid-529 Serine/threonine-protein kinase mTOR inhibitor 1 PubMed PubMed PubMed
CHEMBL2331680 RG-7603 Serine/threonine-protein kinase mTOR inhibitor 1 PubMed
CHEMBL3544963 DS-3078a Serine/threonine-protein kinase mTOR inhibitor 1 DOI Other
CHEMBL3545006 PWT-33587 Serine/threonine-protein kinase mTOR inhibitor 1 DOI Other
CHEMBL3545056 INK-128 Serine/threonine-protein kinase mTOR inhibitor 1 PubMed PubMed
CHEMBL3545248 DS-7423 Serine/threonine-protein kinase mTOR inhibitor 1 PubMed
CHEMBL3545322 Panulisib Serine/threonine-protein kinase mTOR inhibitor 1 PubMed
CHEMBL3545323 PWT-33579 Serine/threonine-protein kinase mTOR inhibitor 1
CHEMBL3545426 CC-115 Serine/threonine-protein kinase mTOR inhibitor 1 PubMed
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198793
Ensembl ENSG00000198793
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0005764 (lysosome)
GO:0005765 (lysosomal membrane)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005942 (phosphatidylinositol 3-kinase complex)
GO:0012505 (endomembrane system)
GO:0016020 (membrane)
GO:0016605 (PML body)
GO:0030425 (dendrite)
GO:0031090 (organelle membrane)
GO:0031931 (TORC1 complex)
GO:0031932 (TORC2 complex)
GO:0032991 (macromolecular complex)
GO:0043025 (neuronal cell body)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0001030 (RNA polymerase III type 1 promoter DNA binding)
GO:0001031 (RNA polymerase III type 2 promoter DNA binding)
GO:0001032 (RNA polymerase III type 3 promoter DNA binding)
GO:0001156 (TFIIIC-class transcription factor binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO:0019904 (protein domain specific binding)
GO:0043022 (ribosome binding)
GO:0044877 (macromolecular complex binding)
GO:0051219 (phosphoprotein binding)
GO Biological Process GO:0001933 (negative regulation of protein phosphorylation)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0003007 (heart morphogenesis)
GO:0003179 (heart valve morphogenesis)
GO:0005979 (regulation of glycogen biosynthetic process)
GO:0006109 (regulation of carbohydrate metabolic process)
GO:0006112 (energy reserve metabolic process)
GO:0006207 (de novo pyrimidine nucleobase biosynthetic process)
GO:0006281 (DNA repair)
GO:0006468 (protein phosphorylation)
GO:0006950 (response to stress)
GO:0007050 (cell cycle arrest)
GO:0007165 (signal transduction)
GO:0007281 (germ cell development)
GO:0007420 (brain development)
GO:0007569 (cell aging)
GO:0007584 (response to nutrient)
GO:0007616 (long-term memory)
GO:0008542 (visual learning)
GO:0009791 (post-embryonic development)
GO:0010507 (negative regulation of autophagy)
GO:0010592 (positive regulation of lamellipodium assembly)
GO:0010628 (positive regulation of gene expression)
GO:0010831 (positive regulation of myotube differentiation)
GO:0010942 (positive regulation of cell death)
GO:0010976 (positive regulation of neuron projection development)
GO:0014042 (positive regulation of neuron maturation)
GO:0014736 (negative regulation of muscle atrophy)
GO:0016049 (cell growth)
GO:0016236 (macroautophagy)
GO:0016242 (negative regulation of macroautophagy)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0021510 (spinal cord development)
GO:0030030 (cell projection organization)
GO:0030163 (protein catabolic process)
GO:0030838 (positive regulation of actin filament polymerization)
GO:0031295 (T cell costimulation)
GO:0031397 (negative regulation of protein ubiquitination)
GO:0031529 (ruffle organization)
GO:0031641 (regulation of myelination)
GO:0031669 (cellular response to nutrient levels)
GO:0031929 (TOR signaling)
GO:0031998 (regulation of fatty acid beta-oxidation)
GO:0032095 (regulation of response to food)
GO:0032868 (response to insulin)
GO:0032956 (regulation of actin cytoskeleton organization)
GO:0035176 (social behavior)
GO:0035264 (multicellular organism growth)
GO:0040007 (growth)
GO:0042060 (wound healing)
GO:0042220 (response to cocaine)
GO:0043087 (regulation of GTPase activity)
GO:0043200 (response to amino acid)
GO:0043278 (response to morphine)
GO:0043610 (regulation of carbohydrate utilization)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0045670 (regulation of osteoclast differentiation)
GO:0045727 (positive regulation of translation)
GO:0045792 (negative regulation of cell size)
GO:0045859 (regulation of protein kinase activity)
GO:0045945 (positive regulation of transcription from RNA polymerase III promoter)
GO:0046777 (protein autophosphorylation)
GO:0046889 (positive regulation of lipid biosynthetic process)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0048255 (mRNA stabilization)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0048714 (positive regulation of oligodendrocyte differentiation)
GO:0048738 (cardiac muscle tissue development)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050769 (positive regulation of neurogenesis)
GO:0050882 (voluntary musculoskeletal movement)
GO:0051496 (positive regulation of stress fiber assembly)
GO:0051534 (negative regulation of NFAT protein import into nucleus)
GO:0051896 (regulation of protein kinase B signaling)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0055006 (cardiac cell development)
GO:0055013 (cardiac muscle cell development)
GO:0060048 (cardiac muscle contraction)
GO:0060135 (maternal process involved in female pregnancy)
GO:0060252 (positive regulation of glial cell proliferation)
GO:0060999 (positive regulation of dendritic spine development)
GO:0061051 (positive regulation of cell growth involved in cardiac muscle cell development)
GO:0071456 (cellular response to hypoxia)
GO:0090335 (regulation of brown fat cell differentiation)
GO:0090559 (regulation of membrane permeability)
GO:1900034 (regulation of cellular response to heat)
GO:1901216 (positive regulation of neuron death)
GO:1901838 (positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter)
GO:1904000 (positive regulation of eating behavior)
GO:1904056 (positive regulation of cholangiocyte proliferation)
GO:1904058 (positive regulation of sensory perception of pain)
GO:1904193 (negative regulation of cholangiocyte apoptotic process)
GO:1904197 (positive regulation of granulosa cell proliferation)
GO:1904206 (positive regulation of skeletal muscle hypertrophy)
GO:1904213 (negative regulation of iodide transmembrane transport)
Wikipedia Mammalian_target_of_rapamycin

Target Cross References - Protein

canSAR P42345
Human Protein Atlas ENSG00000198793
IntAct P42345
Guide to Pharmacology 2109
Open Targets ENSG00000198793
PharmGKB PA28360
Pharos P42345 (Tclin)
Reactome R-HSA-1257604 (PIP3 activates AKT signaling.)
R-HSA-1632852 (Macroautophagy.)
R-HSA-165159 (mTOR signalling.)
R-HSA-166208 (mTORC1-mediated signalling.)
R-HSA-3371571 (HSF1-dependent transactivation.)
R-HSA-380972 (Energy dependent regulation of mTOR by LKB1-AMPK.)
R-HSA-389357 (CD28 dependent PI3K/Akt signaling.)
R-HSA-5218920 (VEGFR2 mediated vascular permeability.)
R-HSA-5628897 (TP53 Regulates Metabolic Genes.)
R-HSA-5674400 (Constitutive Signaling by AKT1 E17K in Cancer.)
R-HSA-6804757 (Regulation of TP53 Degradation.)
UniProt P42345 Q4LE76 Q5TER1 Q6LE87 Q96QG3 Q9Y4I3

Target Cross References - Domain

InterPro IPR000403 (PI3/4_kinase_cat_dom.)
IPR003151 (PIK-rel_kinase_FAT.)
IPR003152 (FATC_dom.)
IPR009076 (FRB_dom.)
IPR011009 (Kinase-like_dom.)
IPR011989 (ARM-like.)
IPR011990 (TPR-like_helical_dom.)
IPR014009 (PIK_FAT.)
IPR016024 (ARM-type_fold.)
IPR018936 (PI3/4_kinase_CS.)
IPR024585 (DUF3385_TOR.)
IPR026683 (TOR.)
Pfam PF00454 (PI3_PI4_kinase)
PF02259 (FAT)
PF02260 (FATC)
PF08771 (FRB_dom)
PF11865 (DUF3385)

Target Cross References - Structure

PDBe 1AUE 1FAP 1NSG 2FAP 3FAP 4DRH 4DRI 4DRJ 4FAP 4JSN 4JSP 4JSV 4JSX 4JT5 4JT6 5GPG
CREDO 1AUE 1FAP 1NSG 2FAP 3FAP 4DRH 4DRI 4DRJ 4FAP 4JSN 4JSP 4JSV 4JSX 4JT5 4JT6 5GPG
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