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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2842
Target Type SINGLE PROTEIN
Preferred Name FK506 binding protein 12
Synonyms FK506-binding protein 12-rapamycin complex-associated protein 1 | FKBP12-rapamycin complex-associated protein | FRAP | FRAP1 | FRAP2 | MTOR | Mammalian target of rapamycin | Mechanistic target of rapamycin | RAFT1 | RAPT1 | Rapamycin and FKBP12 target 1 | Rapamycin target protein 1 | Serine/threonine-protein kinase mTOR | mTOR
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase mTOR SINGLE PROTEIN P42345

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2221341 Mammalian target of Rapamycin (mTORC1) PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198793
Ensembl ENSG00000198793
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005741 (mitochondrial outer membrane)
GO:0005764 (lysosome)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005942 (phosphatidylinositol 3-kinase complex)
GO:0016605 (PML body)
GO:0031931 (TORC1 complex)
GO:0031932 (TORC2 complex)
GO Molecular Function GO:0004674 (protein serine/threonine kinase activity)
GO:0005524 (ATP binding)
GO:0051219 (phosphoprotein binding)
GO Biological Process GO:0007584 (response to nutrient)
GO:0008286 (insulin receptor signaling pathway)
GO:0016049 (cell growth)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0030163 (protein catabolic process)
GO:0031295 (T cell costimulation)
GO:0031929 (TOR signaling cascade)
GO:0043200 (response to amino acid stimulus)
GO:0046777 (protein autophosphorylation)
GO:0048011 (nerve growth factor receptor signaling pathway)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0071456 (cellular response to hypoxia)
Wikipedia Mammalian_target_of_rapamycin

Target Cross References - Protein

canSAR P42345
Human Protein Atlas ENSG00000198793
IntAct P42345
Guide to Pharmacology 2109 (mechanistic target of rapamycin (serine/threonine kinase))
PharmGKB PA28360
Reactome REACT_11061 (Signalling by NGF.)
REACT_498 (Signaling by Insulin receptor.)
REACT_6900 (Signaling in Immune system.)
UniProt P42345 Q4LE76 Q5TER1 Q6LE87 Q96QG3 Q9Y4I3

Target Cross References - Domain

InterPro IPR000403 (PI3/4_kinase_cat.)
IPR003151 (PIK-rel_kinase_FAT.)
IPR003152 (FATC.)
IPR009076 (FKBP_rapamycin-assoc_FKBP12-bd.)
IPR011009 (Kinase-like_dom.)
IPR011989 (ARM-like.)
IPR014009 (PIK_FAT.)
IPR016024 (ARM-type_fold.)
IPR018936 (PI3/4_kinase_CS.)
Pfam PF00454 (PI3_PI4_kinase)
PF02259 (FAT)
PF02260 (FATC)
PF08771 (Rapamycin_bind)

Target Cross References - Structure

PDBe 1AUE 1FAP 1NSG 2FAP 3FAP 4FAP
CREDO 1AUE 1FAP 1NSG 2FAP 3FAP 4FAP
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