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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL284
Target Type SINGLE PROTEIN
Preferred Name Dipeptidyl peptidase IV
Synonyms ADABP | ADCP-2 | ADCP2 | Adenosine deaminase complexing protein 2 | CD26 | CD_antigen=CD26 | DPP IV | DPP4 | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase 4 | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | Dipeptidyl peptidase IV | T-cell activation antigen CD26 | TP103
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease sc clan > serine protease s9b subfamily

Target Components

Component Description Relationship Accession
Dipeptidyl peptidase 4 SINGLE PROTEIN P27487

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111469 Dipeptidyl peptidase II and dipeptidyl peptidase IV (DPP2 and DPP4) SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL142703 VILDAGLIPTIN Dipeptidyl peptidase IV inhibitor 4 Other PubMed
CHEMBL227529 ALOGLIPTIN BENZOATE Dipeptidyl peptidase IV inhibitor 4 DailyMed
CHEMBL237500 LINAGLIPTIN Dipeptidyl peptidase IV inhibitor 4 DailyMed
CHEMBL1201174 SITAGLIPTIN PHOSPHATE Dipeptidyl peptidase IV inhibitor 4 DailyMed
CHEMBL1201743 SAXAGLIPTIN HYDROCHLORIDE Dipeptidyl peptidase IV inhibitor 4 DailyMed
CHEMBL515387 GOSOGLIPTIN Dipeptidyl peptidase IV inhibitor 3 PubMed
CHEMBL2105754 TRELAGLIPTIN SUCCINATE Dipeptidyl peptidase IV inhibitor 3 PubMed
CHEMBL2105762 OMARIGLIPTIN Dipeptidyl peptidase IV inhibitor 3 PubMed
CHEMBL3833357 BEGELOMAB Dipeptidyl peptidase IV inhibitor 3 Other Other
CHEMBL591118 CARMEGLIPTIN Dipeptidyl peptidase IV inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000197635
Ensembl ENSG00000197635
GO Cellular Component GO:0005576 (extracellular region)
GO:0005765 (lysosomal membrane)
GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0030027 (lamellipodium)
GO:0030054 (cell junction)
GO:0030139 (endocytic vesicle)
GO:0031258 (lamellipodium membrane)
GO:0042995 (cell projection)
GO:0045121 (membrane raft)
GO:0046581 (intercellular canaliculus)
GO:0070062 (extracellular exosome)
GO:0071438 (invadopodium membrane)
GO Molecular Function GO:0001618 (virus receptor activity)
GO:0002020 (protease binding)
GO:0004177 (aminopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0008239 (dipeptidyl-peptidase activity)
GO:0016787 (hydrolase activity)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0001662 (behavioral fear response)
GO:0001666 (response to hypoxia)
GO:0006508 (proteolysis)
GO:0007155 (cell adhesion)
GO:0008284 (positive regulation of cell proliferation)
GO:0010716 (negative regulation of extracellular matrix disassembly)
GO:0031295 (T cell costimulation)
GO:0033632 (regulation of cell-cell adhesion mediated by integrin)
GO:0035641 (locomotory exploration behavior)
GO:0036343 (psychomotor behavior)
GO:0042110 (T cell activation)
GO:0043542 (endothelial cell migration)
GO:0046718 (viral entry into host cell)
GO:0050796 (regulation of insulin secretion)
Wikipedia Dipeptidyl_peptidase-4

Target Cross References - Protein

canSAR P27487
Human Protein Atlas ENSG00000197635
IntAct P27487
Guide to Pharmacology 1612
Open Targets ENSG00000197635
PharmGKB PA27467
Reactome R-HSA-381771 (Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).)
R-HSA-400511 (Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).)
UniProt P27487 Q53TN1

Target Cross References - Domain

InterPro IPR001375 (Peptidase_S9.)
IPR002469 (Peptidase_S9B_N.)
IPR002471 (Pept_S9_AS.)
IPR029058 (AB_hydrolase.)
Pfam PF00326 (Peptidase_S9)
PF00930 (DPPIV_N)

Target Cross References - Structure

PDBe 1J2E 1N1M 1NU6 1NU8 1PFQ 1R9M 1R9N 1RWQ 1TK3 1TKR 1U8E 1W1I 1WCY 1X70 2AJL 2BGN 2BGR 2BUB 2FJP 2G5P 2G5T 2G63 2HHA 2I03 More...
CREDO 1J2E 1N1M 1NU6 1NU8 1PFQ 1R9M 1R9N 1RWQ 1TK3 1TKR 1U8E 1W1I 1WCY 1X70 2AJL 2BGN 2BGR 2BUB 2FJP 2G5P 2G5T 2G63 2HHA 2I03 More...
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