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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2835
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase JAK1
Synonyms JAK-1 | JAK1 | JAK1A | JAK1B | Janus kinase 1 | Tyrosine-protein kinase JAK1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase jaka family
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase jakb family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase JAK1 SINGLE PROTEIN P23458

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3301391 JAK1/TYK2 PROTEIN COMPLEX
CHEMBL3301390 JAK1/JAK2/TYK2 PROTEIN COMPLEX
CHEMBL2363062 Janus Kinase (JAK) PROTEIN FAMILY
CHEMBL3038491 JAK3/JAK1 PROTEIN COMPLEX
CHEMBL3038492 JAK2/JAK1 PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1795071 RUXOLITINIB PHOSPHATE Tyrosine-protein kinase JAK1 inhibitor 4 FDA
CHEMBL2105759 BARICITINIB Tyrosine-protein kinase JAK1 inhibitor 4 PubMed
CHEMBL1078178 MOMELOTINIB Tyrosine-protein kinase JAK1 inhibitor 3 PubMed PubMed
CHEMBL3301607 FILGOTINIB Tyrosine-protein kinase JAK1 inhibitor 3 PubMed
CHEMBL3301606 SOLCITINIB Tyrosine-protein kinase JAK1 inhibitor 2 Other PubMed
CHEMBL3544929 PF-04965842 Tyrosine-protein kinase JAK1 inhibitor 2 Other PubMed
CHEMBL3545225 INCB-047986 Tyrosine-protein kinase JAK1 inhibitor 2 PubMed
CHEMBL3545284 Cerdulatinib Tyrosine-protein kinase JAK1 inhibitor 2 Other PubMed
CHEMBL3622820 ITACITINIB Tyrosine-protein kinase JAK1 inhibitor 2 PubMed PubMed
CHEMBL2106468 TRICETAMIDE Tyrosine-protein kinase JAK1 inhibitor 1 PubMed PubMed
CHEMBL3545249 GLPG-0555 Tyrosine-protein kinase JAK1 inhibitor 1 Other
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000162434
Ensembl ENSG00000162434
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005925 (focal adhesion)
GO:0012505 (endomembrane system)
GO:0016020 (membrane)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005102 (receptor binding)
GO:0005131 (growth hormone receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019903 (protein phosphatase binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0031730 (CCR5 chemokine receptor binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0006468 (protein phosphorylation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0030154 (cell differentiation)
GO:0035556 (intracellular signal transduction)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0038110 (interleukin-2-mediated signaling pathway)
GO:0042127 (regulation of cell proliferation)
GO:0043547 (positive regulation of GTPase activity)
GO:0045087 (innate immune response)
GO:0046677 (response to antibiotic)
GO:0046777 (protein autophosphorylation)
GO:0060333 (interferon-gamma-mediated signaling pathway)
GO:0060334 (regulation of interferon-gamma-mediated signaling pathway)
GO:0060337 (type I interferon signaling pathway)
GO:0060338 (regulation of type I interferon-mediated signaling pathway)
GO:1903672 (positive regulation of sprouting angiogenesis)
Wikipedia Janus_kinase_1

Target Cross References - Protein

canSAR P23458
Human Protein Atlas ENSG00000162434
IntAct P23458
Guide to Pharmacology 2047
Open Targets ENSG00000162434
PharmGKB PA29988
Pharos P23458 (Tclin)
Reactome R-HSA-1059683 (Interleukin-6 signaling.)
R-HSA-110056 (MAPK3 (ERK1) activation.)
R-HSA-112411 (MAPK1 (ERK2) activation.)
R-HSA-114604 (GPVI-mediated activation cascade.)
R-HSA-1169408 (ISG15 antiviral mechanism.)
R-HSA-1266695 (Interleukin-7 signaling.)
R-HSA-392451 (G beta:gamma signalling through PI3Kgamma.)
R-HSA-451927 (Interleukin-2 signaling.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
R-HSA-6783783 (Interleukin-10 signaling.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-6788467 (IL-6-type cytokine receptor ligand interactions.)
R-HSA-877300 (Interferon gamma signaling.)
R-HSA-877312 (Regulation of IFNG signaling.)
R-HSA-909733 (Interferon alpha/beta signaling.)
R-HSA-912526 (Interleukin receptor SHC signaling.)
R-HSA-912694 (Regulation of IFNA signaling.)
UniProt P23458 Q59GQ2 Q9UD26

Target Cross References - Domain

InterPro IPR000299 (FERM_domain.)
IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR011993 (PH_dom-like.)
IPR016251 (Tyr_kinase_non-rcpt_Jak/Tyk2.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR019748 (FERM_central.)
IPR019749 (Band_41_domain.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR020776 (Tyr_kinase_non-rcpt_Jak1.)
Pfam PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 3EYG 3EYH 4E4L 4E4N 4E5W 4EHZ 4EI4 4FK6 4GS0 4I5C 4IVB 4IVC 4IVD 4K6Z 4K77 4L00 4L01 5E1E 5HX8 5IXD 5IXI 5KHW 5KHX 5L04
CREDO 3EYG 3EYH 4E4L 4E4N 4E5W 4EHZ 4EI4 4FK6 4GS0 4I5C 4IVB 4IVC 4IVD 4K6Z 4K77 4L00 4L01 5E1E 5HX8 5IXD 5IXI 5KHW 5KHX 5L04
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