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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL283
Target Type SINGLE PROTEIN
Preferred Name Matrix metalloproteinase 3
Synonyms MMP-3 | MMP3 | Matrix metalloproteinase-3 | SL-1 | STMY1 | Stromelysin-1 | Transin-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m10a subfamily

Target Components

Component Description Relationship Accession
Stromelysin-1 SINGLE PROTEIN P08254

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111321 Matrix metalloproteinase (2 and 3) SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000149968
Ensembl ENSG00000149968
GO Cellular Component GO:0005578 (proteinaceous extracellular matrix)
GO:0005615 (extracellular space)
GO:0005576 (extracellular region)
GO Molecular Function GO:0005509 (calcium ion binding)
GO:0004175 (endopeptidase activity)
GO:0004222 (metalloendopeptidase activity)
GO:0008270 (zinc ion binding)
GO Biological Process GO:0032461 (positive regulation of protein oligomerization)
GO:0010727 (negative regulation of hydrogen peroxide metabolic process)
GO:0071230 (cellular response to amino acid stimulus)
GO:0022617 (extracellular matrix disassembly)
GO:0030574 (collagen catabolic process)
GO:0030198 (extracellular matrix organization)
GO:0030334 (regulation of cell migration)
GO:0006508 (proteolysis)
GO:1903209 (positive regulation of oxidative stress-induced cell death)
GO:0071732 (cellular response to nitric oxide)
Wikipedia MMP3

Target Cross References - Protein

canSAR P08254
Human Protein Atlas ENSG00000149968
IntAct P08254
Guide to Pharmacology 1630 (MMP3)
PharmGKB PA30886
UniProt Q3B7S0 Q6GRF8 P08254 B2R8B8

Target Cross References - Domain

InterPro IPR024079 (MetalloPept_cat_dom.)
IPR018486 (Hemopexin_CS.)
IPR006026 (Peptidase_Metallo.)
IPR021190 (Pept_M10A.)
IPR028700 (Stromelysin_1.)
IPR001818 (Pept_M10_metallopeptidase.)
IPR018487 (Hemopexin-like_repeat.)
IPR016293 (Pept_M10A_stromelysin-type.)
IPR021158 (Pept_M10A_Zn_BS.)
IPR002477 (Peptidoglycan-bd-like.)
IPR000585 (Hemopexin-like_dom.)
Pfam PF00413 (Peptidase_M10)
PF01471 (PG_binding_1)
PF00045 (Hemopexin)

Target Cross References - Structure

PDBe 1B8Y 1HFS 2USN 1D7X 1D8M 2D1O 3OHO 4JA1 1UEA 1CIZ 1CQR 1D5J 1G05 1HY7 1QIA 4G9L 1QIC 1B3D 1BQO 1G4K 1SLN 4DPE 1SLM 1BIW More...
CREDO 1B8Y 1HFS 2USN 1D7X 1D8M 2D1O 3OHO 4JA1 1UEA 1CIZ 1CQR 1D5J 1G05 1HY7 1QIA 4G9L 1QIC 1B3D 1BQO 1G4K 1SLN 4DPE 1SLM 1BIW More...
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