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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2826
Preferred Name Subtilisin/kexin type 5
Synonyms PC5 | PC5 | PC6 | PC6 | PCSK5 | Proprotein convertase 5 | Proprotein convertase 6 | Proprotein convertase subtilisin/kexin type 5 | Subtilisin/kexin-like protease PC5 | hPC6
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease sb clan > serine protease s8b subfamily

Target Components

Component Description Relationship Accession
Proprotein convertase subtilisin/kexin type 5 SINGLE PROTEIN Q92824

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000099139
Ensembl ENSG00000099139
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005794 (Golgi apparatus)
GO:0005796 (Golgi lumen)
GO:0012505 (endomembrane system)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030141 (secretory granule)
GO Molecular Function GO:0004175 (endopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO:0042277 (peptide binding)
GO Biological Process GO:0001822 (kidney development)
GO:0002001 (renin secretion into blood stream)
GO:0003279 (cardiac septum development)
GO:0006465 (signal peptide processing)
GO:0006508 (proteolysis)
GO:0007267 (cell-cell signaling)
GO:0007368 (determination of left/right symmetry)
GO:0007507 (heart development)
GO:0007565 (female pregnancy)
GO:0007566 (embryo implantation)
GO:0009952 (anterior/posterior pattern specification)
GO:0016485 (protein processing)
GO:0016486 (peptide hormone processing)
GO:0019058 (viral life cycle)
GO:0030323 (respiratory tube development)
GO:0032455 (nerve growth factor processing)
GO:0035108 (limb morphogenesis)
GO:0042089 (cytokine biosynthetic process)
GO:0043043 (peptide biosynthetic process)
GO:0048566 (embryonic digestive tract development)
GO:0048706 (embryonic skeletal system development)
GO:0060976 (coronary vasculature development)
Wikipedia PCSK5

Target Cross References - Protein

Human Protein Atlas ENSG00000099139
IntAct Q92824
Guide to Pharmacology 2385
Open Targets ENSG00000099139
PharmGKB PA33093
Reactome R-HSA-167060 (NGF processing.)
R-HSA-174800 (Chylomicron-mediated lipid transport.)
UniProt F5H2G7 Q13527 Q92824 Q96EP4

Target Cross References - Domain

InterPro IPR000209 (Peptidase_S8/S53_dom.)
IPR000742 (EGF-like_dom.)
IPR002884 (PrprotnconvertsP.)
IPR006212 (Furin_repeat.)
IPR008979 (Galactose-bd-like.)
IPR009020 (Propept_inh.)
IPR009030 (Growth_fac_rcpt_.)
IPR011641 (Tyr-kin_ephrin_A/B_rcpt-like.)
IPR015500 (Peptidase_S8_subtilisin-rel.)
IPR022398 (Peptidase_S8_His-AS.)
IPR023827 (Peptidase_S8_Asp-AS.)
IPR023828 (Peptidase_S8_Ser-AS.)
IPR032778 (GF_recep_IV.)
IPR032815 (S8_pro-domain.)
IPR034182 (Kexin/furin.)
Pfam PF00082 (Peptidase_S8)
PF01483 (P_proprotein)
PF14843 (GF_recep_IV)
PF16470 (S8_pro-domain)