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ChEMBL

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Target Report Card

Target Name and Classification

Target ID CHEMBL2823
Target Type SINGLE PROTEIN
Preferred Name Heme oxygenase 1
Synonyms HMOX1 | HO | HO-1 | HO1 | Heme oxygenase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Heme oxygenase 1 SINGLE PROTEIN P09601

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100292
Ensembl ENSG00000100292
GO Cellular Component GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005730 (nucleolus)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005829 (cytosol)
GO:0005901 (caveola)
GO:0016020 (membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0004392 (heme oxygenase (decyclizing) activity)
GO:0004630 (phospholipase D activity)
GO:0004871 (signal transducer activity)
GO:0005515 (protein binding)
GO:0016491 (oxidoreductase activity)
GO:0019899 (enzyme binding)
GO:0020037 (heme binding)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001666 (response to hypoxia)
GO:0001935 (endothelial cell proliferation)
GO:0002246 (wound healing involved in inflammatory response)
GO:0002686 (negative regulation of leukocyte migration)
GO:0006788 (heme oxidation)
GO:0006879 (cellular iron ion homeostasis)
GO:0006915 (apoptotic process)
GO:0006979 (response to oxidative stress)
GO:0007264 (small GTPase mediated signal transduction)
GO:0007588 (excretion)
GO:0008217 (regulation of blood pressure)
GO:0008219 (cell death)
GO:0008285 (negative regulation of cell proliferation)
GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage)
GO:0010656 (negative regulation of muscle cell apoptotic process)
GO:0014806 (smooth muscle hyperplasia)
GO:0016239 (positive regulation of macroautophagy)
GO:0016242 (negative regulation of macroautophagy)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0031670 (cellular response to nutrient)
GO:0032764 (negative regulation of mast cell cytokine production)
GO:0034101 (erythrocyte homeostasis)
GO:0034383 (low-density lipoprotein particle clearance)
GO:0034395 (regulation of transcription from RNA polymerase II promoter in response to iron)
GO:0034605 (cellular response to heat)
GO:0035094 (response to nicotine)
GO:0035556 (intracellular signal transduction)
GO:0042167 (heme catabolic process)
GO:0042168 (heme metabolic process)
GO:0042542 (response to hydrogen peroxide)
GO:0043065 (positive regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043305 (negative regulation of mast cell degranulation)
GO:0043392 (negative regulation of DNA binding)
GO:0043433 (negative regulation of sequence-specific DNA binding transcription factor activity)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0043619 (regulation of transcription from RNA polymerase II promoter in response to oxidative stress)
GO:0043627 (response to estrogen)
GO:0045080 (positive regulation of chemokine biosynthetic process)
GO:0045765 (regulation of angiogenesis)
GO:0045766 (positive regulation of angiogenesis)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0048662 (negative regulation of smooth muscle cell proliferation)
GO:0051090 (regulation of sequence-specific DNA binding transcription factor activity)
GO:0051260 (protein homooligomerization)
GO:0055072 (iron ion homeostasis)
GO:0055114 (oxidation-reduction process)
GO:0071243 (cellular response to arsenic-containing substance)
GO:0071276 (cellular response to cadmium ion)
GO:0071456 (cellular response to hypoxia)
GO:0072719 (cellular response to cisplatin)
GO:0090050 (positive regulation of cell migration involved in sprouting angiogenesis)
GO:0097421 (liver regeneration)
GO:0097755 (positive regulation of blood vessel diameter)
GO:1902042 (negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)
GO:1903589 (positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)
GO:1904036 (negative regulation of epithelial cell apoptotic process)
GO:1904706 (negative regulation of vascular smooth muscle cell proliferation)
Wikipedia HMOX1

Target Cross References - Protein

canSAR P09601
CGD Heme oxygenase 1 deficiency
Human Protein Atlas ENSG00000100292
IntAct P09601
Guide to Pharmacology 1441
Open Targets ENSG00000100292
PharmGKB PA29341
Reactome R-HSA-189483 (Heme degradation.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-917937 (Iron uptake and transport.)
UniProt P09601

Target Cross References - Domain

InterPro IPR002051 (Haem_Oase.)
IPR016053 (Haem_Oase-like.)
IPR016084 (Haem_Oase-like_multi-hlx.)
IPR018207 (Haem_oxygenase_CS.)
Pfam PF01126 (Heme_oxygenase)

Target Cross References - Structure

PDBe 1N3U 1N45 1NI6 1OYK 1OYL 1OZE 1OZL 1OZR 1OZW 1S13 1S8C 1T5P 1TWN 1TWR 1XJZ 1XK0 1XK1 1XK2 1XK3 3CZY 3HOK 3K4F 3TGM 4WD4 More...
CREDO 1N3U 1N45 1NI6 1OYK 1OYL 1OZE 1OZL 1OZR 1OZW 1S13 1S8C 1T5P 1TWN 1TWR 1XJZ 1XK0 1XK1 1XK2 1XK3 3CZY 3HOK 3K4F 3TGM 4WD4 More...
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