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Target Report Card

Target Name and Classification

Target ID CHEMBL2816
Target Type SINGLE PROTEIN
Preferred Name Alpha-ketoglutarate dehydrogenase
Synonyms 2-oxoglutarate dehydrogenase complex component E1 | 2-oxoglutarate dehydrogenase, mitochondrial | Alpha-ketoglutarate dehydrogenase | OGDC-E1 | OGDH
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
2-oxoglutarate dehydrogenase, mitochondrial SINGLE PROTEIN Q02218

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000105953
Ensembl ENSG00000105953
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005759 (mitochondrial matrix)
GO:0005829 (cytosol)
GO:0031966 (mitochondrial membrane)
GO:0045252 (oxoglutarate dehydrogenase complex)
GO Molecular Function GO:0004591 (oxoglutarate dehydrogenase (succinyl-transferring) activity)
GO:0016491 (oxidoreductase activity)
GO:0016624 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor)
GO:0030976 (thiamine pyrophosphate binding)
GO:0031072 (heat shock protein binding)
GO:0034602 (oxoglutarate dehydrogenase (NAD+) activity)
GO:0046872 (metal ion binding)
GO:0051087 (chaperone binding)
GO Biological Process GO:0006091 (generation of precursor metabolites and energy)
GO:0006096 (glycolytic process)
GO:0006099 (tricarboxylic acid cycle)
GO:0006103 (2-oxoglutarate metabolic process)
GO:0006104 (succinyl-CoA metabolic process)
GO:0006554 (lysine catabolic process)
GO:0006734 (NADH metabolic process)
GO:0008152 (metabolic process)
GO:0021695 (cerebellar cortex development)
GO:0021756 (striatum development)
GO:0021766 (hippocampus development)
GO:0021794 (thalamus development)
GO:0021860 (pyramidal neuron development)
GO:0022028 (tangential migration from the subventricular zone to the olfactory bulb)
GO:0046487 (glyoxylate metabolic process)
GO:0055114 (oxidation-reduction process)
GO:0061034 (olfactory bulb mitral cell layer development)
Wikipedia OGDH

Target Cross References - Protein

canSAR Q02218
Human Protein Atlas ENSG00000105953
IntAct Q02218
Open Targets ENSG00000105953
PharmGKB PA31910
Reactome R-HSA-389661 (Glyoxylate metabolism and glycine degradation.)
R-HSA-71064 (Lysine catabolism.)
R-HSA-71403 (Citric acid cycle (TCA cycle).)
UniProt B4E2U9 D3DVL0 E9PBM1 Q02218 Q96DD3 Q9UDX0

Target Cross References - Domain

InterPro IPR001017 (DH_E1.)
IPR005475 (Transketolase-like_Pyr-bd.)
IPR011603 (2oxoglutarate_DH_E1.)
IPR029061 (THDP-binding.)
IPR031717 (KGD_C.)
IPR032106 (2-oxogl_dehyd_N.)
Pfam PF00676 (E1_dh)
PF02779 (Transket_pyr)
PF16078 (2-oxogl_dehyd_N)
PF16870 (OxoGdeHyase_C)

Target Cross References - Structure

PDBe 3ERY
CREDO 3ERY
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