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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2816
Target Type SINGLE PROTEIN
Preferred Name Alpha-ketoglutarate dehydrogenase
Synonyms 2-oxoglutarate dehydrogenase complex component E1 | 2-oxoglutarate dehydrogenase, mitochondrial | Alpha-ketoglutarate dehydrogenase | OGDC-E1 | OGDH
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
2-oxoglutarate dehydrogenase, mitochondrial SINGLE PROTEIN Q02218

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000105953
Ensembl ENSG00000105953
GO Cellular Component GO:0005759 (mitochondrial matrix)
GO:0031966 (mitochondrial membrane)
GO Molecular Function GO:0004591 (oxoglutarate dehydrogenase (succinyl-transferring) activity)
GO:0030976 (thiamine pyrophosphate binding)
GO Biological Process GO:0006096 (glycolysis)
GO:0006099 (tricarboxylic acid cycle)
GO:0006554 (lysine catabolic process)
Wikipedia OGDH

Target Cross References - Protein

canSAR Q02218
Human Protein Atlas ENSG00000105953
IntAct Q02218
PharmGKB PA31910
Reactome REACT_1046 (Pyruvate metabolism and Citric Acid (TCA) cycle.)
REACT_13 (Metabolism of amino acids and derivatives.)
UniProt D3DVL0 Q02218 Q9UDX0

Target Cross References - Domain

InterPro IPR001017 (DH_E1.)
IPR005475 (Transketolase-like_Pyr-bd.)
IPR011603 (2oxoglutarate_DH_E1.)
Pfam PF00676 (E1_dh)
PF02779 (Transket_pyr)

Target Cross References - Structure

PDBe 3ERY
CREDO 3ERY
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