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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2815
Target Type SINGLE PROTEIN
Preferred Name Nerve growth factor receptor Trk-A
Synonyms High affinity nerve growth factor receptor | MTC | NTRK1 | Neurotrophic tyrosine kinase receptor type 1 | TRK | TRK1-transforming tyrosine kinase protein | TRKA | Trk-A | Tropomyosin-related kinase A | Tyrosine kinase receptor | Tyrosine kinase receptor A | gp140trk | p140-TrkA
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase trk family

Target Components

Component Description Relationship Accession
High affinity nerve growth factor receptor SINGLE PROTEIN P04629

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198400
Ensembl ENSG00000198400
GO Cellular Component GO:0005768 (endosome)
GO:0005887 (integral to plasma membrane)
GO Molecular Function GO:0004675 (transmembrane receptor protein serine/threonine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005030 (neurotrophin receptor activity)
GO:0005524 (ATP binding)
GO Biological Process GO:0000186 (activation of MAPKK activity)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007202 (activation of phospholipase C activity)
GO:0007265 (Ras protein signal transduction)
GO:0007399 (nervous system development)
GO:0030154 (cell differentiation)
GO:0048011 (nerve growth factor receptor signaling pathway)
GO:0048015 (phosphatidylinositol-mediated signaling)
Wikipedia TrkA_receptor

Target Cross References - Protein

canSAR P04629
CGD Insensitivity to pain, congenital, with anhidrosis
Human Protein Atlas ENSG00000198400
IntAct P04629
Guide to Pharmacology 1817 (neurotrophic tyrosine kinase, receptor, type 1)
PharmGKB PA31817
Reactome REACT_11061 (Signalling by NGF.)
UniProt B2R6T5 B7ZM34 P04629 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7

Target Cross References - Domain

InterPro IPR000483 (Cys-rich_flank_reg_C.)
IPR000719 (Prot_kinase_cat_dom.)
IPR001245 (Ser-Thr/Tyr-Pkinase.)
IPR002011 (Tyr_prot_kinase_rcpt_2_CS.)
IPR003599 (Ig_sub.)
IPR007110 (Ig-like.)
IPR008266 (Tyr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR013783 (Ig-like_fold.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020461 (Tyr_kinase_neurotrophic_rcpt_1.)
IPR020635 (Tyr_Pkinase_cat_dom.)
IPR020777 (Tyr_prot_kinase_NGF_rcpt.)
Pfam PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1HE7 1WWA 1WWW 2IFG
CREDO 1HE7 1WWA 1WWW 2IFG
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