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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2815
Target Type SINGLE PROTEIN
Preferred Name Nerve growth factor receptor Trk-A
Synonyms High affinity nerve growth factor receptor | MTC | NTRK1 | Neurotrophic tyrosine kinase receptor type 1 | TRK | TRK1-transforming tyrosine kinase protein | TRKA | Trk-A | Tropomyosin-related kinase A | Tyrosine kinase receptor A | Tyrosine kinase receptor | gp140trk | p140-TrkA
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase trk family

Target Components

Component Description Relationship Accession
High affinity nerve growth factor receptor SINGLE PROTEIN P04629

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3559684 Neurotrophic tyrosine kinase receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL603469 LESTAURTINIB Nerve growth factor receptor Trk-A inhibitor 3 PubMed
CHEMBL564829 MILCICLIB Nerve growth factor receptor Trk-A inhibitor 2 PubMed PubMed
CHEMBL3545152 CT-327 Nerve growth factor receptor Trk-A inhibitor 2 Other PubMed
CHEMBL3545179 AZD-7451 Nerve growth factor receptor Trk-A inhibitor 1 PubMed PubMed
CHEMBL3545381 PLX-7486 Nerve growth factor receptor Trk-A inhibitor 1 Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198400
Ensembl ENSG00000198400
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005770 (late endosome)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0031410 (cytoplasmic vesicle)
GO:0031901 (early endosome membrane)
GO:0031902 (late endosome membrane)
GO:0043025 (neuronal cell body)
GO:0043234 (protein complex)
GO:0043235 (receptor complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005004 (GPI-linked ephrin receptor activity)
GO:0005030 (neurotrophin receptor activity)
GO:0005166 (neurotrophin p75 receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0010465 (nerve growth factor receptor activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019900 (kinase binding)
GO:0042803 (protein homodimerization activity)
GO:0043121 (neurotrophin binding)
GO:0048406 (nerve growth factor binding)
GO Biological Process GO:0000186 (activation of MAPKK activity)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0006468 (protein phosphorylation)
GO:0007018 (microtubule-based movement)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007275 (multicellular organism development)
GO:0007399 (nervous system development)
GO:0007411 (axon guidance)
GO:0007568 (aging)
GO:0007611 (learning or memory)
GO:0007623 (circadian rhythm)
GO:0008285 (negative regulation of cell proliferation)
GO:0009314 (response to radiation)
GO:0010623 (programmed cell death involved in cell development)
GO:0010976 (positive regulation of neuron projection development)
GO:0014823 (response to activity)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0019233 (sensory perception of pain)
GO:0021553 (olfactory nerve development)
GO:0030154 (cell differentiation)
GO:0030183 (B cell differentiation)
GO:0031667 (response to nutrient levels)
GO:0035094 (response to nicotine)
GO:0038180 (nerve growth factor signaling pathway)
GO:0042490 (mechanoreceptor differentiation)
GO:0042493 (response to drug)
GO:0043068 (positive regulation of programmed cell death)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0043547 (positive regulation of GTPase activity)
GO:0045471 (response to ethanol)
GO:0045766 (positive regulation of angiogenesis)
GO:0046579 (positive regulation of Ras protein signal transduction)
GO:0046777 (protein autophosphorylation)
GO:0048011 (neurotrophin TRK receptor signaling pathway)
GO:0048013 (ephrin receptor signaling pathway)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0048485 (sympathetic nervous system development)
GO:0048678 (response to axon injury)
GO:0050965 (detection of temperature stimulus involved in sensory perception of pain)
GO:0050966 (detection of mechanical stimulus involved in sensory perception of pain)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051599 (response to hydrostatic pressure)
GO:0051602 (response to electrical stimulus)
GO:0051965 (positive regulation of synapse assembly)
GO:0051968 (positive regulation of synaptic transmission, glutamatergic)
GO:0060009 (Sertoli cell development)
GO:0060384 (innervation)
GO:0060385 (axonogenesis involved in innervation)
GO:0061368 (behavioral response to formalin induced pain)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0071316 (cellular response to nicotine)
GO:0071363 (cellular response to growth factor stimulus)
GO:1901215 (negative regulation of neuron death)
GO:1990090 (cellular response to nerve growth factor stimulus)
Wikipedia TrkA_receptor

Target Cross References - Protein

canSAR P04629
CGD Insensitivity to pain, congenital, with anhidrosis
Human Protein Atlas ENSG00000198400
IntAct P04629
Guide to Pharmacology 1817
Open Targets ENSG00000198400
PharmGKB PA31817
Pharos P04629 (Tchem)
Reactome R-HSA-167021 (PLC-gamma1 signalling.)
R-HSA-167044 (Signalling to RAS.)
R-HSA-170968 (Frs2-mediated activation.)
R-HSA-170984 (ARMS-mediated activation.)
R-HSA-177504 (Retrograde neurotrophin signalling.)
R-HSA-187024 (NGF-independant TRKA activation.)
R-HSA-187042 (TRKA activation by NGF.)
R-HSA-187706 (Signalling to p38 via RIT and RIN.)
R-HSA-198203 (PI3K/AKT activation.)
R-HSA-198745 (Signalling to STAT3.)
UniProt B2R6T5 B7ZM34 P04629 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7

Target Cross References - Domain

InterPro IPR000483 (Cys-rich_flank_reg_C.)
IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001611 (Leu-rich_rpt.)
IPR002011 (Tyr_kinase_rcpt_2_CS.)
IPR007110 (Ig-like_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR013783 (Ig-like_fold.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020461 (Tyr_kinase_neurotrophic_rcpt_1.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR020777 (Tyr_kinase_NGF_rcpt.)
IPR031635 (NTRK_C2.)
IPR032675 (L_dom-like.)
Pfam PF07714 (Pkinase_Tyr)
PF13855 (LRR_8)
PF16920 (TPKR_C2)

Target Cross References - Structure

PDBe 1HE7 1WWA 1WWW 2IFG 4AOJ 4F0I 4GT5 4PMM 4PMP 4PMS 4PMT 4YNE 4YPS
CREDO 1HE7 1WWA 1WWW 2IFG 4AOJ 4F0I 4GT5 4PMM 4PMP 4PMS 4PMT 4YNE 4YPS
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