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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2810
Target Type SINGLE PROTEIN
Preferred Name Protein-glutamine gamma-glutamyltransferase K
Synonyms Epidermal TGase | KTG | Protein-glutamine gamma-glutamyltransferase K | TG(K) | TGK | TGM1 | TGase K | TGase-1 | Transglutaminase K | Transglutaminase-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Protein-glutamine gamma-glutamyltransferase K SINGLE PROTEIN P22735

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000092295
Ensembl ENSG00000092295
GO Cellular Component GO:0001533 (cornified envelope)
GO:0031224 (intrinsic to membrane)
GO Molecular Function GO:0003810 (protein-glutamine gamma-glutamyltransferase activity)
GO:0005515 (protein binding)
GO:0008415 (acyltransferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0018149 (peptide cross-linking)
GO:0031424 (keratinization)
GO:0043163 (cell envelope organization)
Wikipedia Keratinocyte_transglutaminase

Target Cross References - Protein

canSAR P22735
CGD Ichthyosis, lamellar, 1; Ichthyosiform erythroderma, congenital
Human Protein Atlas ENSG00000092295
PharmGKB PA36490
UniProt P22735 Q197M4

Target Cross References - Domain

InterPro IPR001102 (Transglutaminase_N.)
IPR002931 (Transglutaminase-like.)
IPR008958 (Transglutaminase_C.)
IPR013783 (Ig-like_fold.)
IPR013808 (Transglutaminase_CS.)
IPR014756 (Ig_E-set.)
IPR023608 (Gln_gamma-glutamylTfrase_euk.)
Pfam PF00868 (Transglut_N)
PF00927 (Transglut_C)
PF01841 (Transglut_core)

Target Cross References - Structure

PDBe 2XZZ
CREDO 2XZZ
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