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Target Report Card

Target Name and Classification

Target ID CHEMBL2801
Preferred Name CaM kinase II delta
Synonyms CAMK2D | CAMKD | CaM kinase II subunit delta | CaMK-II subunit delta | Calcium/calmodulin-dependent protein kinase type II subunit delta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase camk2 family

Target Components

Component Description Relationship Accession
Calcium/calmodulin-dependent protein kinase type II subunit delta SINGLE PROTEIN Q13557

Target Relations

ChEMBL ID Pref Name Target Type

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000145349
Ensembl ENSG00000145349
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0014704 (intercalated disc)
GO:0016020 (membrane)
GO:0016529 (sarcoplasmic reticulum)
GO:0030315 (T-tubule)
GO:0030666 (endocytic vesicle membrane)
GO:0031594 (neuromuscular junction)
GO:0033017 (sarcoplasmic reticulum membrane)
GO:0034704 (calcium channel complex)
GO:0042383 (sarcolemma)
GO:0043025 (neuronal cell body)
GO:0043194 (axon initial segment)
GO:0043234 (protein complex)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004683 (calmodulin-dependent protein kinase activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019871 (sodium channel inhibitor activity)
GO:0031432 (titin binding)
GO:0042803 (protein homodimerization activity)
GO:0044325 (ion channel binding)
GO:0050998 (nitric-oxide synthase binding)
GO Biological Process GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0000165 (MAPK cascade)
GO:0001558 (regulation of cell growth)
GO:0001666 (response to hypoxia)
GO:0002026 (regulation of the force of heart contraction)
GO:0002028 (regulation of sodium ion transport)
GO:0003254 (regulation of membrane depolarization)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006468 (protein phosphorylation)
GO:0006816 (calcium ion transport)
GO:0008016 (regulation of heart contraction)
GO:0010389 (regulation of G2/M transition of mitotic cell cycle)
GO:0010613 (positive regulation of cardiac muscle hypertrophy)
GO:0010649 (regulation of cell communication by electrical coupling)
GO:0010666 (positive regulation of cardiac muscle cell apoptotic process)
GO:0010880 (regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)
GO:0010881 (regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)
GO:0014911 (positive regulation of smooth muscle cell migration)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0030007 (cellular potassium ion homeostasis)
GO:0032469 (endoplasmic reticulum calcium ion homeostasis)
GO:0035022 (positive regulation of Rac protein signal transduction)
GO:0043547 (positive regulation of GTPase activity)
GO:0046777 (protein autophosphorylation)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0051259 (protein oligomerization)
GO:0055119 (relaxation of cardiac muscle)
GO:0060048 (cardiac muscle contraction)
GO:0060314 (regulation of ryanodine-sensitive calcium-release channel activity)
GO:0060333 (interferon-gamma-mediated signaling pathway)
GO:0060341 (regulation of cellular localization)
GO:0061049 (cell growth involved in cardiac muscle cell development)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0071277 (cellular response to calcium ion)
GO:0086003 (cardiac muscle cell contraction)
GO:0086091 (regulation of heart rate by cardiac conduction)
GO:0098901 (regulation of cardiac muscle cell action potential)
GO:0098909 (regulation of cardiac muscle cell action potential involved in regulation of contraction)
GO:1900034 (regulation of cellular response to heat)
GO:1901725 (regulation of histone deacetylase activity)
GO:1901844 (regulation of cell communication by electrical coupling involved in cardiac conduction)
GO:1901897 (regulation of relaxation of cardiac muscle)
GO:1902306 (negative regulation of sodium ion transmembrane transport)
GO:1902514 (regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)
GO:2000650 (negative regulation of sodium ion transmembrane transporter activity)
Wikipedia CAMK2D

Target Cross References - Protein

canSAR Q13557
Human Protein Atlas ENSG00000145349
IntAct Q13557
Guide to Pharmacology 1558
Open Targets ENSG00000145349
PharmGKB PA92
Pharos Q13557 (Tchem)
Reactome R-HSA-3371571 (HSF1-dependent transactivation.)
R-HSA-399719 (Trafficking of AMPA receptors.)
R-HSA-438066 (Unblocking of NMDA receptor, glutamate binding and activation.)
R-HSA-442729 (CREB phosphorylation through the activation of CaMKII.)
R-HSA-442742 (CREB phosphorylation through the activation of Ras.)
R-HSA-442982 (Ras activation uopn Ca2+ infux through NMDA receptor.)
R-HSA-5576892 (Phase 0 - rapid depolarisation.)
R-HSA-5578775 (Ion homeostasis.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
R-HSA-877300 (Interferon gamma signaling.)
R-HSA-936837 (Ion transport by P-type ATPases.)
UniProt A8MVS8 Q13557 Q52PK4 Q59G21 Q8N553 Q9UGH6 Q9UQE9

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR013543 (Ca/CaM-dep_prot_kinase-assoc.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020636 (Ca/CaM-dep_Ca-dep_prot_Kinase.)
IPR032710 (NTF2-like_dom.)
Pfam PF00069 (Pkinase)
PF08332 (CaMKII_AD)

Target Cross References - Structure

PDBe 2VN9 2W2C 2WEL 3GP2