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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL280
Target Type SINGLE PROTEIN
Preferred Name Matrix metalloproteinase 13
Synonyms Collagenase 3 | MMP-13 | MMP13 | Matrix metalloproteinase-13
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m10a subfamily

Target Components

Component Description Relationship Accession
Collagenase 3 SINGLE PROTEIN P45452

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111422 Matrix metalloproteinase (1 and 13) SELECTIVITY GROUP
CHEMBL2095216 Collagenase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1200567 DOXYCYCLINE HYCLATE Matrix metalloproteinase 13 inhibitor 4 DailyMed PubMed PubMed PubMed
CHEMBL1200699 DOXYCYCLINE HYDRATE Matrix metalloproteinase 13 inhibitor 4 DailyMed PubMed PubMed PubMed
CHEMBL2364574 DOXYCYCLINE CALCIUM Matrix metalloproteinase 13 inhibitor 4 DailyMed PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000137745
Ensembl ENSG00000137745
GO Cellular Component GO:0005615 (extracellular space)
GO Molecular Function GO:0004222 (metalloendopeptidase activity)
GO:0008270 (zinc ion binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0030574 (collagen catabolic process)
Wikipedia Matrix_metallopeptidase_13

Target Cross References - Protein

canSAR P45452
CGD Spondyloepimetaphyseal dysplasia, Missouri type; Metaphyseal anadysplasia 1
Human Protein Atlas ENSG00000137745
Guide to Pharmacology 1637 (MMP13)
PharmGKB PA30871
UniProt P45452

Target Cross References - Domain

InterPro IPR000585 (Hemopexin/matrixin.)
IPR001818 (Pept_M10_metallopeptidase.)
IPR002477 (Peptidoglycan-bd-like.)
IPR006026 (Peptidase_Metallo.)
IPR016293 (Pept_M10A_matrix_strom.)
IPR018486 (Hemopexin/matrixin_CS.)
IPR018487 (Hemopexin/matrixin_repeat.)
IPR021158 (Pept_M10A_Zn_BS.)
IPR021190 (Pept_M10A_matrixin.)
Pfam PF00045 (Hemopexin)
PF00413 (Peptidase_M10)
PF01471 (PG_binding_1)

Target Cross References - Structure

PDBe 1PEX 1XUC 1XUD 1XUR 1YOU 1ZTQ 2D1N 2E2D 2OW9 2OZR 2PJT 3ELM 3I7G 3I7I 3KEC 3KEJ 3KEK 3KRY 3LJZ 456C 830C
CREDO 1PEX 1XUC 1XUD 1XUR 1YOU 1ZTQ 2D1N 2E2D 2OW9 2OZR 2PJT 3ELM 3I7G 3I7I 3KEC 3KEJ 3KEK 3KRY 3LJZ 456C 830C
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