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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL280
Target Type SINGLE PROTEIN
Preferred Name Matrix metalloproteinase 13
Synonyms Collagenase 3 | MMP-13 | MMP13 | Matrix metalloproteinase-13
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m10a subfamily

Target Components

Component Description Relationship Accession
Collagenase 3 SINGLE PROTEIN P45452

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111422 Matrix metalloproteinase (1 and 13) SELECTIVITY GROUP
CHEMBL2095216 Collagenase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1200567 DOXYCYCLINE HYCLATE Matrix metalloproteinase 13 inhibitor 4 DailyMed PubMed PubMed PubMed
CHEMBL1200699 DOXYCYCLINE HYDRATE Matrix metalloproteinase 13 inhibitor 4 DailyMed PubMed PubMed PubMed
CHEMBL2364574 DOXYCYCLINE CALCIUM Matrix metalloproteinase 13 inhibitor 4 DailyMed PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000137745
Ensembl ENSG00000137745
GO Cellular Component GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0005615 (extracellular space)
GO:0005764 (lysosome)
GO:0005794 (Golgi apparatus)
GO:0031012 (extracellular matrix)
GO:0046581 (intercellular canaliculus)
GO Molecular Function GO:0001968 (fibronectin binding)
GO:0004222 (metalloendopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0005509 (calcium ion binding)
GO:0005518 (collagen binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO:0048306 (calcium-dependent protein binding)
GO:0050750 (low-density lipoprotein particle receptor binding)
GO Biological Process GO:0001503 (ossification)
GO:0001554 (luteolysis)
GO:0001649 (osteoblast differentiation)
GO:0001666 (response to hypoxia)
GO:0001958 (endochondral ossification)
GO:0003417 (growth plate cartilage development)
GO:0006508 (proteolysis)
GO:0007507 (heart development)
GO:0007567 (parturition)
GO:0009612 (response to mechanical stimulus)
GO:0022617 (extracellular matrix disassembly)
GO:0030282 (bone mineralization)
GO:0030574 (collagen catabolic process)
GO:0035116 (embryonic hindlimb morphogenesis)
GO:0042493 (response to drug)
GO:0043171 (peptide catabolic process)
GO:0043627 (response to estrogen)
GO:0044267 (cellular protein metabolic process)
GO:0044849 (estrous cycle)
GO:0051216 (cartilage development)
GO:0060349 (bone morphogenesis)
GO:0071498 (cellular response to fluid shear stress)
GO:1904244 (positive regulation of pancreatic trypsinogen secretion)
Wikipedia Matrix_metallopeptidase_13

Target Cross References - Protein

canSAR P45452
CGD Spondyloepimetaphyseal dysplasia, Missouri type; Metaphyseal anadysplasia 1
Human Protein Atlas ENSG00000137745
Guide to Pharmacology 1637
Open Targets ENSG00000137745
PharmGKB PA30871
Reactome R-HSA-1442490 (Collagen degradation.)
R-HSA-1474228 (Degradation of the extracellular matrix.)
R-HSA-1592389 (Activation of Matrix Metalloproteinases.)
R-HSA-2022090 (Assembly of collagen fibrils and other multimeric structures.)
UniProt A8K846 B2RCZ3 P45452 Q6NWN6

Target Cross References - Domain

InterPro IPR000585 (Hemopexin-like_dom.)
IPR001818 (Pept_M10_metallopeptidase.)
IPR002477 (Peptidoglycan-bd-like.)
IPR006026 (Peptidase_Metallo.)
IPR016293 (Pept_M10A_stromelysin-type.)
IPR018486 (Hemopexin_CS.)
IPR018487 (Hemopexin-like_repeat.)
IPR021158 (Pept_M10A_Zn_BS.)
IPR021190 (Pept_M10A.)
IPR024079 (MetalloPept_cat_dom.)
IPR028711 (Collagenase_3.)
IPR033739 (M10A_MMP.)
Pfam PF00045 (Hemopexin)
PF00413 (Peptidase_M10)
PF01471 (PG_binding_1)

Target Cross References - Structure

PDBe 1PEX 1XUC 1XUD 1XUR 1YOU 1ZTQ 2D1N 2E2D 2OW9 2OZR 2PJT 2YIG 3ELM 3I7G 3I7I 3KEC 3KEJ 3KEK 3KRY 3LJZ 3O2X 3TVC 3WV1 3WV2 More...
CREDO 1PEX 1XUC 1XUD 1XUR 1YOU 1ZTQ 2D1N 2E2D 2OW9 2OZR 2PJT 2YIG 3ELM 3I7G 3I7I 3KEC 3KEJ 3KEK 3KRY 3LJZ 3O2X 3TVC 3WV1 3WV2 More...
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