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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2793
Target Type SINGLE PROTEIN
Preferred Name Casein kinase I alpha
Synonyms CK1 | CKI-alpha | CSNK1A1 | Casein kinase I isoform alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ck1 protein kinase group > ck1 protein kinase ck1 family

Target Components

Component Description Relationship Accession
Casein kinase I isoform alpha SINGLE PROTEIN P48729

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038493 Casein kinase I/MDM2 PROTEIN COMPLEX
CHEMBL2111458 Casein kinase I PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000113712
Ensembl ENSG00000113712
GO Cellular Component GO:0000777 (condensed chromosome kinetochore)
GO:0005813 (centrosome)
GO:0005829 (cytosol)
GO:0016607 (nuclear speck)
GO Molecular Function GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007067 (mitosis)
GO:0016055 (Wnt receptor signaling pathway)
GO:0051301 (cell division)
Wikipedia Casein_kinase_1,_alpha_1

Target Cross References - Protein

canSAR P48729
Human Protein Atlas ENSG00000113712
IntAct P48729
Guide to Pharmacology 1995 (casein kinase 1, alpha 1)
PharmGKB PA26951
Reactome REACT_11045 (Signaling by Wnt.)
UniProt D3DQG0 D3DQG1 P48729 Q4JJA0 Q5U046 Q5U047 Q6FGA2 Q96HD2 Q9UDK3

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)
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