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ChEMBL

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Target Report Card

Target Name and Classification

Target ID CHEMBL2793
Target Type SINGLE PROTEIN
Preferred Name Casein kinase I alpha
Synonyms CK1 | CKI-alpha | CSNK1A1 | Casein kinase I isoform alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ck1 protein kinase group > ck1 protein kinase ck1 family

Target Components

Component Description Relationship Accession
Casein kinase I isoform alpha SINGLE PROTEIN P48729

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111458 Casein kinase I PROTEIN FAMILY
CHEMBL3038493 Casein kinase I/MDM2 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000113712
Ensembl ENSG00000113712
GO Cellular Component GO:0000775 (chromosome, centromeric region)
GO:0000776 (kinetochore)
GO:0000777 (condensed chromosome kinetochore)
GO:0005634 (nucleus)
GO:0005694 (chromosome)
GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0005815 (microtubule organizing center)
GO:0005829 (cytosol)
GO:0005847 (mRNA cleavage and polyadenylation specificity factor complex)
GO:0005856 (cytoskeleton)
GO:0016020 (membrane)
GO:0016607 (nuclear speck)
GO:0030877 (beta-catenin destruction complex)
GO:0045095 (keratin filament)
GO:0072372 (primary cilium)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006909 (phagocytosis)
GO:0007030 (Golgi organization)
GO:0007049 (cell cycle)
GO:0007067 (mitotic nuclear division)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0008360 (regulation of cell shape)
GO:0016055 (Wnt signaling pathway)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process)
GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process)
GO:0045104 (intermediate filament cytoskeleton organization)
GO:0051301 (cell division)
GO:0090090 (negative regulation of canonical Wnt signaling pathway)
GO:1904424 (regulation of GTP binding)
GO:1904885 (beta-catenin destruction complex assembly)
GO:1904886 (beta-catenin destruction complex disassembly)
Wikipedia Casein_kinase_1,_alpha_1

Target Cross References - Protein

canSAR P48729
Human Protein Atlas ENSG00000113712
IntAct P48729
Guide to Pharmacology 1995
Open Targets ENSG00000113712
PharmGKB PA26951
Pharos P48729 (Tchem)
Reactome R-HSA-195253 (Degradation of beta-catenin by the destruction complex.)
R-HSA-196299 (Beta-catenin phosphorylation cascade.)
R-HSA-4641262 (Disassembly of the destruction complex and recruitment of AXIN to the membrane.)
R-HSA-5339716 (Misspliced GSK3beta mutants stabilize beta-catenin.)
R-HSA-5358747 (S33 mutants of beta-catenin aren't phosphorylated.)
R-HSA-5358749 (S37 mutants of beta-catenin aren't phosphorylated.)
R-HSA-5358751 (S45 mutants of beta-catenin aren't phosphorylated.)
R-HSA-5358752 (T41 mutants of beta-catenin aren't phosphorylated.)
R-HSA-5467337 (APC truncation mutants have impaired AXIN binding.)
R-HSA-5467340 (AXIN missense mutants destabilize the destruction complex.)
R-HSA-5467348 (Truncations of AMER1 destabilize the destruction complex.)
R-HSA-5610783 (Degradation of GLI2 by the proteasome.)
R-HSA-5610785 (GLI3 is processed to GLI3R by the proteasome.)
R-HSA-5635838 (Activation of SMO.)
UniProt D3DQG0 D3DQG1 P48729 Q4JJA0 Q5U046 Q5U047 Q6FGA2 Q71TU5 Q96HD2 Q9UDK3

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 5FQD
CREDO 5FQD
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