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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL279
Target Type SINGLE PROTEIN
Preferred Name Vascular endothelial growth factor receptor 2
Synonyms CD_antigen=CD309 | FLK-1 | FLK1 | Fetal liver kinase 1 | KDR | KDR | Kinase insert domain receptor | Protein-tyrosine kinase receptor flk-1 | VEGFR-2 | VEGFR2 | Vascular endothelial growth factor receptor 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase vegfr family

Target Components

Component Description Relationship Accession
Vascular endothelial growth factor receptor 2 SINGLE PROTEIN P35968

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111434 VEGF-receptor 2 and Fibroblast growth factor receptor 2 SELECTIVITY GROUP
CHEMBL2095227 Vascular endothelial growth factor receptor PROTEIN FAMILY
CHEMBL2111375 Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2) SELECTIVITY GROUP
CHEMBL2111336 VEGF-receptor 2 and tyrosine-protein kinase SRC SELECTIVITY GROUP
CHEMBL2111409 Vascular endothelial growth factor receptor 2 and 3 (KDR and Flt-4) SELECTIVITY GROUP
CHEMBL2111440 VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta) SELECTIVITY GROUP
CHEMBL2111480 Vascular endothelial growth factor receptor 1 and 2 (Flt-1 and KDR) SELECTIVITY GROUP
CHEMBL2111428 VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT) SELECTIVITY GROUP
CHEMBL2111439 VEGF-receptor 2 and Fibroblast growth factor receptor 1 PROTEIN FAMILY

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL2103868 CABOZANTINIB S-MALATE Vascular endothelial growth factor receptor 2 inhibitor DailyMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000128052
Ensembl ENSG00000128052
GO Cellular Component GO:0005887 (integral to plasma membrane)
GO Molecular Function GO:0004716 (receptor signaling protein tyrosine kinase activity)
GO:0005021 (vascular endothelial growth factor receptor activity)
GO:0005178 (integrin binding)
GO:0005524 (ATP binding)
GO:0019838 (growth factor binding)
GO:0051879 (Hsp90 protein binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0006468 (protein phosphorylation)
GO:0008360 (regulation of cell shape)
GO:0010595 (positive regulation of endothelial cell migration)
GO:0030154 (cell differentiation)
GO:0044419 (interspecies interaction between organisms)
GO:0050927 (positive regulation of positive chemotaxis)
GO:0051894 (positive regulation of focal adhesion assembly)
Wikipedia Kinase_insert_domain_receptor

Target Cross References - Protein

canSAR P35968
Human Protein Atlas ENSG00000128052
IntAct P35968
PharmGKB PA30086
Reactome REACT_12529 (Signaling by VEGF.)
UniProt O60723 P35968 Q14178

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR001245 (Ser-Thr/Tyr-Pkinase.)
IPR001824 (Tyr_prot_kinase_rcpt_3_CS.)
IPR003598 (Ig_sub2.)
IPR003599 (Ig_sub.)
IPR007110 (Ig-like.)
IPR008266 (Tyr_prot_kinase_AS.)
IPR009134 (Tyr_prot_kinase_VEGFR_rcpt_N.)
IPR009136 (Tyr_prot_kinase_VEGFR2_rcpt.)
IPR011009 (Kinase-like_dom.)
IPR013098 (Ig_I-set.)
IPR013106 (Ig_V-set.)
IPR013783 (Ig-like_fold.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_Pkinase_cat_dom.)
Pfam PF07679 (I-set)
PF07686 (V-set)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1VR2 1Y6A 1Y6B 1YWN 2OH4 2P2H 2P2I 2QU5 2QU6 2RL5 2X1W 2X1X 2XIR 3B8Q 3B8R 3BE2 3C7Q 3CJF 3CJG 3CP9 3CPB 3CPC 3DTW 3EFL More...
CREDO 1VR2 1Y6A 1Y6B 1YWN 2OH4 2P2H 2P2I 2QU5 2QU6 2RL5 2X1W 2X1X 2XIR 3B8Q 3B8R 3BE2 3C7Q 3CJF 3CJG 3CP9 3CPB 3CPC 3DTW 3EFL More...
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