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Target Report Card

Target Name and Classification

Target ID CHEMBL2781
Target Type SINGLE PROTEIN
Preferred Name Sodium/hydrogen exchanger 1
Synonyms APNH | APNH1 | NHE-1 | NHE1 | Na(+)/H(+) antiporter, amiloride-sensitive | Na(+)/H(+) exchanger 1 | SLC9A1 | Sodium/hydrogen exchanger 1 | Solute carrier family 9 member 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc09 family of sodium/hydrogen exchangers

Target Components

Component Description Relationship Accession
Sodium/hydrogen exchanger 1 SINGLE PROTEIN P19634

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000090020
Ensembl ENSG00000090020
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005925 (focal adhesion)
GO:0009986 (cell surface)
GO:0014704 (intercalated disc)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0016324 (apical plasma membrane)
GO:0030027 (lamellipodium)
GO:0030315 (T-tubule)
GO:0042383 (sarcolemma)
GO:0045121 (membrane raft)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO:0090533 (cation-transporting ATPase complex)
GO Molecular Function GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0005546 (phosphatidylinositol-4,5-bisphosphate binding)
GO:0015297 (antiporter activity)
GO:0015299 (solute:proton antiporter activity)
GO:0015385 (sodium:proton antiporter activity)
GO:0015386 (potassium:proton antiporter activity)
GO:0030346 (protein phosphatase 2B binding)
GO:0030674 (protein binding, bridging)
GO:0032947 (protein complex scaffold)
GO:0048306 (calcium-dependent protein binding)
GO:0086040 (sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential)
GO Biological Process GO:0002026 (regulation of the force of heart contraction)
GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006812 (cation transport)
GO:0006814 (sodium ion transport)
GO:0006883 (cellular sodium ion homeostasis)
GO:0006885 (regulation of pH)
GO:0010447 (response to acidic pH)
GO:0010613 (positive regulation of cardiac muscle hypertrophy)
GO:0010882 (regulation of cardiac muscle contraction by calcium ion signaling)
GO:0014070 (response to organic cyclic compound)
GO:0016049 (cell growth)
GO:0016477 (cell migration)
GO:0030011 (maintenance of cell polarity)
GO:0030154 (cell differentiation)
GO:0030214 (hyaluronan catabolic process)
GO:0030307 (positive regulation of cell growth)
GO:0032869 (cellular response to insulin stimulus)
GO:0035794 (positive regulation of mitochondrial membrane permeability)
GO:0035994 (response to muscle stretch)
GO:0042493 (response to drug)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0045760 (positive regulation of action potential)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0051259 (protein oligomerization)
GO:0051453 (regulation of intracellular pH)
GO:0051492 (regulation of stress fiber assembly)
GO:0051533 (positive regulation of NFAT protein import into nucleus)
GO:0051893 (regulation of focal adhesion assembly)
GO:0051930 (regulation of sensory perception of pain)
GO:0055007 (cardiac muscle cell differentiation)
GO:0055085 (transmembrane transport)
GO:0070886 (positive regulation of calcineurin-NFAT signaling cascade)
GO:0070997 (neuron death)
GO:0071236 (cellular response to antibiotic)
GO:0071257 (cellular response to electrical stimulus)
GO:0071260 (cellular response to mechanical stimulus)
GO:0071407 (cellular response to organic cyclic compound)
GO:0071436 (sodium ion export)
GO:0071456 (cellular response to hypoxia)
GO:0071468 (cellular response to acidic pH)
GO:0071805 (potassium ion transmembrane transport)
GO:0071872 (cellular response to epinephrine stimulus)
GO:0086003 (cardiac muscle cell contraction)
GO:0086036 (regulation of cardiac muscle cell membrane potential)
GO:0086092 (regulation of the force of heart contraction by cardiac conduction)
GO:0098719 (sodium ion import across plasma membrane)
GO:0098735 (positive regulation of the force of heart contraction)
GO:1902533 (positive regulation of intracellular signal transduction)
GO:1902600 (hydrogen ion transmembrane transport)
GO:1903281 (positive regulation of calcium:sodium antiporter activity)
Wikipedia Sodium%E2%80%93hydrogen_antiporter_1

Target Cross References - Protein

canSAR P19634
Human Protein Atlas ENSG00000090020
IntAct P19634
Open Targets ENSG00000090020
PharmGKB PA35928
Reactome R-HSA-2160916 (Hyaluronan uptake and degradation.)
R-HSA-425986 (Sodium/Proton exchangers.)
UniProt B1ALD6 D3DPL4 P19634 Q96EM2

Target Cross References - Domain

InterPro IPR001970 (Na/H_exchanger_1.)
IPR004709 (NaH_exchanger.)
IPR006153 (Cation/H_exchanger.)
IPR018422 (Cation/H_exchanger_CPA1.)
IPR032103 (NHE_CaM-bd.)
Pfam PF00999 (Na_H_Exchanger)
PF16644 (NEXCaM_BD)

Target Cross References - Structure

PDBe 2BEC 2YGG
CREDO 2BEC 2YGG
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