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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL278
Target Type SINGLE PROTEIN
Preferred Name Integrin alpha-4
Synonyms CD49 antigen-like family member D | CD49D | CD_antigen=CD49d | ITGA4 | Integrin alpha-4 | Integrin alpha-IV | VLA-4 subunit alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Integrin alpha-4 SINGLE PROTEIN P13612

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095184 Integrin alpha-4/beta-7 PROTEIN COMPLEX
CHEMBL1907599 Integrin alpha-4/beta-1 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000115232
Ensembl ENSG00000115232
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0008305 (integrin complex)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0034669 (integrin alpha4-beta7 complex)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0001968 (fibronectin binding)
GO:0003823 (antigen binding)
GO:0005515 (protein binding)
GO:0015026 (coreceptor activity)
GO:0019960 (C-X3-C chemokine binding)
GO:0046872 (metal ion binding)
GO:0050839 (cell adhesion molecule binding)
GO:1990405 (protein antigen binding)
GO Biological Process GO:0002687 (positive regulation of leukocyte migration)
GO:0003366 (cell-matrix adhesion involved in ameboidal cell migration)
GO:0007155 (cell adhesion)
GO:0007159 (leukocyte cell-cell adhesion)
GO:0007160 (cell-matrix adhesion)
GO:0007229 (integrin-mediated signaling pathway)
GO:0030183 (B cell differentiation)
GO:0030198 (extracellular matrix organization)
GO:0034113 (heterotypic cell-cell adhesion)
GO:0034446 (substrate adhesion-dependent cell spreading)
GO:0035987 (endodermal cell differentiation)
GO:0043113 (receptor clustering)
GO:0050776 (regulation of immune response)
GO:0050900 (leukocyte migration)
GO:0050901 (leukocyte tethering or rolling)
GO:0050904 (diapedesis)
GO:0071345 (cellular response to cytokine stimulus)
GO:0090074 (negative regulation of protein homodimerization activity)
GO:0098657 (import into cell)
GO:1903039 (positive regulation of leukocyte cell-cell adhesion)
GO:1903238 (positive regulation of leukocyte tethering or rolling)
GO:1990771 (clathrin-mediated extracellular exosome endocytosis)
GO:2000406 (positive regulation of T cell migration)
Wikipedia CD49d

Target Cross References - Protein

Human Protein Atlas ENSG00000115232
IntAct P13612
Guide to Pharmacology 2443
Open Targets ENSG00000115232
PharmGKB PA29940
Reactome R-HSA-198933 (Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.)
R-HSA-202733 (Cell surface interactions at the vascular wall.)
R-HSA-216083 (Integrin cell surface interactions.)
R-HSA-8949275 (RUNX3 Regulates Immune Response and Cell Migration.)
TIMBAL Integrins
UniProt D3DPG4 P13612 Q7Z4L6

Target Cross References - Domain

InterPro IPR000413 (Integrin_alpha.)
IPR013517 (FG-GAP.)
IPR013519 (Int_alpha_beta-p.)
IPR013649 (Integrin_alpha-2.)
IPR018184 (Integrin_alpha_C_CS.)
IPR028994 (Integrin_alpha_N.)
IPR032695 (Integrin_dom_sf.)
Pfam PF01839 (FG-GAP)
PF08441 (Integrin_alpha2)

Target Cross References - Structure

PDBe 3V4P 3V4V 4HKC 5C7Z 5FPI
CREDO 3V4P 3V4V 4HKC 5C7Z 5FPI
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