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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2777
Target Type SINGLE PROTEIN
Preferred Name myosin light chain kinase 2
Synonyms MLCK2 | MYLK2 | Myosin light chain kinase 2, skeletal/cardiac muscle
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase mlck family

Target Components

Component Description Relationship Accession
Myosin light chain kinase 2, skeletal/cardiac muscle SINGLE PROTEIN Q9H1R3

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000101306
Ensembl ENSG00000101306
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0030017 (sarcomere)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004683 (calmodulin-dependent protein kinase activity)
GO:0004687 (myosin light chain kinase activity)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006941 (striated muscle contraction)
GO:0007274 (neuromuscular synaptic transmission)
GO:0010628 (positive regulation of gene expression)
GO:0014816 (skeletal muscle satellite cell differentiation)
GO:0016310 (phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0032971 (regulation of muscle filament sliding)
GO:0035914 (skeletal muscle cell differentiation)
GO:0046777 (protein autophosphorylation)
GO:0055008 (cardiac muscle tissue morphogenesis)
GO:0060048 (cardiac muscle contraction)
Wikipedia MYLK2

Target Cross References - Protein

canSAR Q9H1R3
CGD Cardiomyopathy, hypertrophic
Human Protein Atlas ENSG00000101306
IntAct Q9H1R3
Guide to Pharmacology 1553
Open Targets ENSG00000101306
PharmGKB PA31389
Pharos Q9H1R3 (Tbio)
UniProt Q569L1 Q96I84 Q9H1R3

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020636 (Ca/CaM-dep_Ca-dep_prot_Kinase.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 3KF9
CREDO 3KF9
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