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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2760
Target Type SINGLE PROTEIN
Preferred Name Sphingomyelin phosphodiesterase
Synonyms ASM | Acid sphingomyelinase | SMPD1 | Sphingomyelin phosphodiesterase | aSMase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Sphingomyelin phosphodiesterase SINGLE PROTEIN P17405

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000166311
Ensembl ENSG00000166311
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005764 (lysosome)
GO:0005768 (endosome)
GO:0005886 (plasma membrane)
GO:0042599 (lamellar body)
GO:0043202 (lysosomal lumen)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004767 (sphingomyelin phosphodiesterase activity)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0016798 (hydrolase activity, acting on glycosyl bonds)
GO:0046872 (metal ion binding)
GO:0061750 (acid sphingomyelin phosphodiesterase activity)
GO Biological Process GO:0006684 (sphingomyelin metabolic process)
GO:0006685 (sphingomyelin catabolic process)
GO:0006687 (glycosphingolipid metabolic process)
GO:0007165 (signal transduction)
GO:0007399 (nervous system development)
GO:0008152 (metabolic process)
GO:0023021 (termination of signal transduction)
GO:0035307 (positive regulation of protein dephosphorylation)
GO:0042220 (response to cocaine)
GO:0042493 (response to drug)
GO:0043065 (positive regulation of apoptotic process)
GO:0043407 (negative regulation of MAP kinase activity)
GO:0046513 (ceramide biosynthetic process)
Wikipedia Sphingomyelin_phosphodiesterase_1

Target Cross References - Protein

canSAR P17405
CGD Niemann-Pick disease, type A; Niemann-Pick disease, type B
Human Protein Atlas ENSG00000166311
IntAct P17405
Open Targets ENSG00000166311
PharmGKB PA35969
Reactome R-HSA-1660662 (Glycosphingolipid metabolism.)
UniProt A8K8M3 E9PKS3 P17405 P17406 Q13811 Q16837 Q16841

Target Cross References - Domain

InterPro IPR004843 (Calcineurin-like_PHP_ApaH.)
IPR008139 (SaposinB_dom.)
IPR011001 (Saposin-like.)
IPR011160 (Sphingomy_PDE.)
IPR029052 (Metallo-depent_PP-like.)
Pfam PF00149 (Metallophos)

Target Cross References - Structure

PDBe 5I81 5I85 5I8R 5JG8
CREDO 5I81 5I85 5I8R 5JG8
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