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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2759
Target Type SINGLE PROTEIN
Preferred Name Cytochrome P450 21
Synonyms 21-OHase | CYP21 | CYP21A2 | CYP21B | Cytochrome P-450c21 | Cytochrome P450 21 | Cytochrome P450 XXI | Cytochrome P450-C21 | Cytochrome P450-C21B | Steroid 21-hydroxylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 21 > cytochrome p450 family 21a > cytochrome p450 21a2

Target Components

Component Description Relationship Accession
Steroid 21-hydroxylase SINGLE PROTEIN P08686

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198457 ENSG00000206338 ENSG00000231852 ENSG00000232414 ENSG00000233151 ENSG00000235134
Ensembl ENSG00000198457 ENSG00000206338 ENSG00000231852 ENSG00000232414 ENSG00000233151 ENSG00000235134
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0004509 (steroid 21-monooxygenase activity)
GO:0005496 (steroid binding)
GO:0005506 (iron ion binding)
GO:0008289 (lipid binding)
GO:0008395 (steroid hydroxylase activity)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006694 (steroid biosynthetic process)
GO:0006704 (glucocorticoid biosynthetic process)
GO:0006705 (mineralocorticoid biosynthetic process)
GO:0008202 (steroid metabolic process)
GO:0016125 (sterol metabolic process)
GO:0055114 (oxidation-reduction process)
Wikipedia 21-Hydroxylase

Target Cross References - Protein

canSAR P08686
CGD Adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency; Hyperandrogenism, nonclassic type, due to 21-hydroxylase deficiency
Human Protein Atlas ENSG00000198457 ENSG00000206338 ENSG00000231852 ENSG00000232414 ENSG00000233151 ENSG00000235134
Open Targets ENSG00000198457 ENSG00000206338 ENSG00000231852 ENSG00000232414 ENSG00000233151 ENSG00000235134
Reactome R-HSA-193993 (Mineralocorticoid biosynthesis.)
R-HSA-194002 (Glucocorticoid biosynthesis.)
R-HSA-211976 (Endogenous sterols.)
R-HSA-5579021 (Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3).)
UniProt A2BHY6 P04033 P08686 Q01204 Q08AG8 Q16749 Q16806 Q5ST44 Q96NU8

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR017972 (Cyt_P450_CS.)
Pfam PF00067 (p450)

Target Cross References - Structure

PDBe 4Y8W
CREDO 4Y8W
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