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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2759
Target Type SINGLE PROTEIN
Preferred Name Cytochrome P450 21
Synonyms Object
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 21 > cytochrome p450 family 21a > cytochrome p450 21a2

Target Components

Component Description Relationship Accession
Steroid 21-hydroxylase SINGLE PROTEIN P08686

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198457 ENSG00000235134
Ensembl ENSG00000198457 ENSG00000235134
GO Cellular Component GO:0005789 (endoplasmic reticulum membrane)
GO Molecular Function GO:0005506 (iron ion binding)
GO:0008395 (steroid hydroxylase activity)
GO:0004509 (steroid 21-monooxygenase activity)
GO:0005496 (steroid binding)
GO:0020037 (heme binding)
GO Biological Process GO:0008202 (steroid metabolic process)
GO:0044281 (small molecule metabolic process)
GO:0006705 (mineralocorticoid biosynthetic process)
GO:0006805 (xenobiotic metabolic process)
GO:0016125 (sterol metabolic process)
GO:0006704 (glucocorticoid biosynthetic process)
Wikipedia 21-Hydroxylase

Target Cross References - Protein

canSAR P08686
CGD Adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency; Hyperandrogenism, nonclassic type, due to 21-hydroxylase deficiency
Human Protein Atlas ENSG00000198457 ENSG00000235134
Guide to Pharmacology 1364 (CYP21A2)
UniProt Q01204 Q08AG8 Q16806 P04033 P08686 Q16749

Target Cross References - Domain

InterPro IPR002401 (Cyt_P450_E_grp-I.)
IPR017972 (Cyt_P450_CS.)
IPR001128 (Cyt_P450.)
Pfam PF00067 (p450)

Target Cross References - Structure

PDBe 4Y8W
CREDO 4Y8W
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