ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL2755
Target Type SINGLE PROTEIN
Preferred Name Glutathione reductase
Synonyms GLUR | GR | GRD1 | GRase | GSR | Glutathione reductase, mitochondrial
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Glutathione reductase, mitochondrial SINGLE PROTEIN P00390

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL513 CARMUSTINE Glutathione reductase inhibitor 4 PubMed
CHEMBL1372 OXIGLUTATIONE Glutathione reductase 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000104687
Ensembl ENSG00000104687
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005759 (mitochondrial matrix)
GO:0005829 (cytosol)
GO:0009897 (external side of plasma membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004362 (glutathione-disulfide reductase activity)
GO:0009055 (electron carrier activity)
GO:0016491 (oxidoreductase activity)
GO:0016668 (oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor)
GO:0050660 (flavin adenine dinucleotide binding)
GO:0050661 (NADP binding)
GO Biological Process GO:0000302 (response to reactive oxygen species)
GO:0006749 (glutathione metabolic process)
GO:0015949 (nucleobase-containing small molecule interconversion)
GO:0045454 (cell redox homeostasis)
GO:0055114 (oxidation-reduction process)
GO:0098869 (cellular oxidant detoxification)
Wikipedia Glutathione_reductase

Target Cross References - Protein

canSAR P00390
Human Protein Atlas ENSG00000104687
IntAct P00390
Open Targets ENSG00000104687
PharmGKB PA29014
Reactome R-HSA-2408550 (Metabolism of ingested H2SeO4 and H2SeO3 into H2Se.)
R-HSA-3299685 (Detoxification of Reactive Oxygen Species.)
R-HSA-499943 (Synthesis and interconversion of nucleotide di- and triphosphates.)
R-HSA-5628897 (TP53 Regulates Metabolic Genes.)
UniProt C8KIL8 C8KIL9 C8KIM0 D3DSV3 P00390 Q7Z5C9 Q9NP63

Target Cross References - Domain

InterPro IPR004099 (Pyr_nucl-diS_OxRdtase_dimer.)
IPR006322 (Glutathione_Rdtase_euk/bac.)
IPR012999 (Pyr_OxRdtase_I_AS.)
IPR016156 (FAD/NAD-linked_Rdtase_dimer.)
IPR023753 (FAD/NAD-binding_dom.)
Pfam PF02852 (Pyr_redox_dim)
PF07992 (Pyr_redox_2)

Target Cross References - Structure

PDBe 1BWC 1DNC 1GRA 1GRB 1GRE 1GRF 1GRG 1GRH 1GRT 1GSN 1K4Q 1XAN 2AAQ 2GH5 2GRT 3DJG 3DJJ 3DK4 3DK8 3DK9 3GRS 3GRT 3SQP 4GR1 More...
CREDO 1BWC 1DNC 1GRA 1GRB 1GRE 1GRF 1GRG 1GRH 1GRT 1GSN 1K4Q 1XAN 2AAQ 2GH5 2GRT 3DJG 3DJJ 3DK4 3DK8 3DK9 3GRS 3GRT 3SQP 4GR1 More...
spacer
spacer