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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2754
Target Type SINGLE PROTEIN
Preferred Name T-cell surface antigen CD4
Synonyms CD4 | CD_antigen=CD4 | T-cell surface antigen T4/Leu-3 | T-cell surface glycoprotein CD4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • surface antigen

Target Components

Component Description Relationship Accession
T-cell surface glycoprotein CD4 SINGLE PROTEIN P01730

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1743029 IBALIZUMAB T-cell surface antigen CD4 inhibitor 3 PubMed PubMed
CHEMBL2108063 ZANOLIMUMAB T-cell surface antigen CD4 other 3
CHEMBL1743083 TREGALIZUMAB T-cell surface antigen CD4 agonist 2 PMC PubMed
CHEMBL2108187 CLENOLIXIMAB T-cell surface antigen CD4 inhibitor 2 PubMed
CHEMBL2108475 PRILIXIMAB T-cell surface antigen CD4 negative modulator 2 Patent PubMed
CHEMBL2108489 KELIXIMAB T-cell surface antigen CD4 negative modulator 2 PubMed
CHEMBL2109474 TRX-1 T-cell surface antigen CD4 inhibitor 2 PubMed
CHEMBL2108266 CEDELIZUMAB T-cell surface antigen CD4 inhibitor 1 DOI ISBN PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000010610
Ensembl ENSG00000010610
GO Cellular Component GO:0005769 (early endosome)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0042101 (T cell receptor complex)
GO:0045121 (membrane raft)
GO Molecular Function GO:0001618 (virus receptor activity)
GO:0001948 (glycoprotein binding)
GO:0004872 (receptor activity)
GO:0004888 (transmembrane signaling receptor activity)
GO:0005201 (extracellular matrix structural constituent)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0015026 (coreceptor activity)
GO:0019865 (immunoglobulin binding)
GO:0019899 (enzyme binding)
GO:0019901 (protein kinase binding)
GO:0042289 (MHC class II protein binding)
GO:0042803 (protein homodimerization activity)
GO:1990782 (protein tyrosine kinase binding)
GO Biological Process GO:0001816 (cytokine production)
GO:0002250 (adaptive immune response)
GO:0002376 (immune system process)
GO:0006948 (induction by virus of host cell-cell fusion)
GO:0006955 (immune response)
GO:0007155 (cell adhesion)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007167 (enzyme linked receptor protein signaling pathway)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0010524 (positive regulation of calcium ion transport into cytosol)
GO:0016032 (viral process)
GO:0019064 (fusion of virus membrane with host plasma membrane)
GO:0030217 (T cell differentiation)
GO:0030260 (entry into host cell)
GO:0031295 (T cell costimulation)
GO:0032355 (response to estradiol)
GO:0032507 (maintenance of protein location in cell)
GO:0033280 (response to vitamin D)
GO:0035397 (helper T cell enhancement of adaptive immune response)
GO:0042102 (positive regulation of T cell proliferation)
GO:0042110 (T cell activation)
GO:0045058 (T cell selection)
GO:0045086 (positive regulation of interleukin-2 biosynthetic process)
GO:0045860 (positive regulation of protein kinase activity)
GO:0050690 (regulation of defense response to virus by virus)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050829 (defense response to Gram-negative bacterium)
GO:0050850 (positive regulation of calcium-mediated signaling)
GO:0050852 (T cell receptor signaling pathway)
GO:0050863 (regulation of T cell activation)
GO:0050870 (positive regulation of T cell activation)
Wikipedia CD4

Target Cross References - Protein

canSAR P01730
CGD OKT4 epitope deficiency
Human Protein Atlas ENSG00000010610
IntAct P01730
Open Targets ENSG00000010610
PharmGKB PA26220
Reactome R-HSA-1462054 (Alpha-defensins.)
R-HSA-167590 (Nef Mediated CD4 Down-regulation.)
R-HSA-173107 (Binding and entry of HIV virion.)
R-HSA-180534 (Vpu mediated degradation of CD4.)
R-HSA-202424 (Downstream TCR signaling.)
R-HSA-202427 (Phosphorylation of CD3 and TCR zeta chains.)
R-HSA-202430 (Translocation of ZAP-70 to Immunological synapse.)
R-HSA-202433 (Generation of second messenger molecules.)
R-HSA-389948 (PD-1 signaling.)
R-HSA-449147 (Signaling by Interleukins.)
R-HSA-8856825 (Cargo recognition for clathrin-mediated endocytosis.)
R-HSA-8856828 (Clathrin-mediated endocytosis.)
UniProt B2R737 D3DUS5 P01730 Q4ZGK2 Q5U066 Q9UDE5

Target Cross References - Domain

InterPro IPR000973 (CD4.)
IPR003598 (Ig_sub2.)
IPR003599 (Ig_sub.)
IPR007110 (Ig-like_dom.)
IPR008424 (Ig_C2-set.)
IPR013106 (Ig_V-set.)
IPR013151 (Immunoglobulin.)
IPR013783 (Ig-like_fold.)
IPR015274 (CD4-extracel.)
IPR021963 (Tcell_CD4_Cterm.)
Pfam PF00047 (ig)
PF05790 (C2-set)
PF09191 (CD4-extracel)
PF12104 (Tcell_CD4_C)

Target Cross References - Structure

PDBe 1CDH 1CDI 1CDJ 1CDU 1CDY 1G9M 1G9N 1GC1 1JL4 1RZJ 1RZK 1WIO 1WIP 1WIQ 2B4C 2JKR 2JKT 2NXY 2NXZ 2NY0 2NY1 2NY2 2NY3 2NY4 More...
CREDO 1CDH 1CDI 1CDJ 1CDU 1CDY 1G9M 1G9N 1GC1 1JL4 1RZJ 1RZK 1WIO 1WIP 1WIQ 2B4C 2JKR 2JKT 2NXY 2NXZ 2NY0 2NY1 2NY2 2NY3 2NY4 More...
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