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Target Report Card

Target Name and Classification

Target ID CHEMBL2743
Target Type SINGLE PROTEIN
Preferred Name cAMP-dependent protein kinase, gamma catalytic subunit
Synonyms PKA C-gamma | PRKACG | cAMP-dependent protein kinase catalytic subunit gamma
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase pka family

Target Components

Component Description Relationship Accession
cAMP-dependent protein kinase catalytic subunit gamma SINGLE PROTEIN P22612

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094138 cAMP-dependent protein kinase (PKA) PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000165059
Ensembl ENSG00000165059
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005829 (cytosol)
GO:0097546 (ciliary base)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004691 (cAMP-dependent protein kinase activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0003091 (renal water homeostasis)
GO:0006468 (protein phosphorylation)
GO:0007283 (spermatogenesis)
GO:0007596 (blood coagulation)
GO:0008584 (male gonad development)
GO:0016310 (phosphorylation)
GO:0034199 (activation of protein kinase A activity)
GO:0042157 (lipoprotein metabolic process)
GO:0071377 (cellular response to glucagon stimulus)
Wikipedia PRKACG

Target Cross References - Protein

canSAR P22612
Human Protein Atlas ENSG00000165059
IntAct P22612
Guide to Pharmacology 1478
Open Targets ENSG00000165059
PharmGKB PA33750
Pharos P22612 (Tbio)
Reactome R-HSA-111931 (PKA-mediated phosphorylation of CREB.)
R-HSA-163358 (PKA-mediated phosphorylation of key metabolic factors.)
R-HSA-163560 (Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.)
R-HSA-163615 (PKA activation.)
R-HSA-164378 (PKA activation in glucagon signalling.)
R-HSA-180024 (DARPP-32 events.)
R-HSA-194223 (HDL-mediated lipid transport.)
R-HSA-381676 (Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.)
R-HSA-392517 (Rap1 signalling.)
R-HSA-422356 (Regulation of insulin secretion.)
R-HSA-432040 (Vasopressin regulates renal water homeostasis via Aquaporins.)
R-HSA-4420097 (VEGFA-VEGFR2 Pathway.)
R-HSA-442720 (CREB phosphorylation through the activation of Adenylate Cyclase.)
R-HSA-5610780 (Degradation of GLI1 by the proteasome.)
R-HSA-5610783 (Degradation of GLI2 by the proteasome.)
R-HSA-5610785 (GLI3 is processed to GLI3R by the proteasome.)
R-HSA-5610787 (Hedgehog 'off' state.)
R-HSA-5621575 (CD209 (DC-SIGN) signaling.)
R-HSA-5687128 (MAPK6/MAPK4 signaling.)
R-HSA-70263 (Gluconeogenesis.)
R-HSA-8853659 (RET signaling.)
R-HSA-983231 (Factors involved in megakaryocyte development and platelet production.)
UniProt O60850 P22612 Q5VZ02 Q86YI1

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)
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