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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2743
Preferred Name cAMP-dependent protein kinase, gamma catalytic subunit
Synonyms PKA C-gamma | PRKACG | cAMP-dependent protein kinase catalytic subunit gamma
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase pka family

Target Components

Component Description Relationship Accession
cAMP-dependent protein kinase catalytic subunit gamma SINGLE PROTEIN P22612

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094138 cAMP-dependent protein kinase (PKA) PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000165059
Ensembl ENSG00000165059
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005829 (cytosol)
GO:0097546 (ciliary base)
GO Molecular Function GO:0004691 (cAMP-dependent protein kinase activity)
GO:0005524 (ATP binding)
GO Biological Process GO:0006094 (gluconeogenesis)
GO:0007165 (signal transduction)
GO:0007596 (blood coagulation)
GO:0044281 (small molecule metabolic process)
GO:0055085 (transmembrane transport)
GO:0007202 (activation of phospholipase C activity)
GO:0048011 (neurotrophin TRK receptor signaling pathway)
GO:0006833 (water transport)
GO:0035556 (intracellular signal transduction)
GO:0045087 (innate immune response)
GO:0003091 (renal water homeostasis)
GO:0006112 (energy reserve metabolic process)
GO:0007283 (spermatogenesis)
GO:0008543 (fibroblast growth factor receptor signaling pathway)
GO:0008584 (male gonad development)
GO:0034199 (activation of protein kinase A activity)
GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0005975 (carbohydrate metabolic process)
GO:0006006 (glucose metabolic process)
GO:0050796 (regulation of insulin secretion)
GO:0071377 (cellular response to glucagon stimulus)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0019433 (triglyceride catabolic process)
Wikipedia PRKACG

Target Cross References - Protein

canSAR P22612
Human Protein Atlas ENSG00000165059
IntAct P22612
Guide to Pharmacology 1478 (protein kinase, cAMP-dependent, catalytic, gamma subunit)
PharmGKB PA33750
UniProt Q5VZ02 Q86YI1 O60850 P22612

Target Cross References - Domain

InterPro IPR008271 (Ser/Thr_kinase_AS.)
IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR002290 (Ser/Thr_dual-sp_kinase.)
IPR011009 (Kinase-like_dom.)
Pfam PF00069 (Pkinase)