ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL2742
Target Type SINGLE PROTEIN
Preferred Name Fibroblast growth factor receptor 3
Synonyms CD_antigen=CD333 | FGFR-3 | FGFR3 | Fibroblast growth factor receptor 3 | JTK4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase fgfr family

Target Components

Component Description Relationship Accession
Fibroblast growth factor receptor 3 SINGLE PROTEIN P22607

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095217 Fibroblast growth factor receptor PROTEIN FAMILY

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL1201733 PAZOPANIB HYDROCHLORIDE Fibroblast growth factor receptor 3 inhibitor DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000068078
Ensembl ENSG00000068078
GO Cellular Component GO:0005887 (integral to plasma membrane)
GO Molecular Function GO:0005007 (fibroblast growth factor receptor activity)
GO:0005524 (ATP binding)
GO:0017134 (fibroblast growth factor binding)
GO:0042802 (identical protein binding)
GO Biological Process GO:0000165 (MAPKKK cascade)
GO:0006468 (protein phosphorylation)
GO:0007259 (JAK-STAT cascade)
GO:0008284 (positive regulation of cell proliferation)
GO:0008286 (insulin receptor signaling pathway)
GO:0016049 (cell growth)
GO:0048640 (negative regulation of developmental growth)
GO:0070977 (bone maturation)
Wikipedia Fibroblast_growth_factor_receptor_3

Target Cross References - Protein

canSAR P22607
CGD Camptodactyly, tall stature, and hearing loss (CATSHL) syndrome; Crouzon syndrome with acanthosis nigricans; Muenke syndrome
Human Protein Atlas ENSG00000068078
IntAct P22607
Guide to Pharmacology 1810 (fibroblast growth factor receptor 3)
PharmGKB PA28129
Reactome REACT_498 (Signaling by Insulin receptor.)
REACT_9470 (Signaling by FGFR.)
UniProt D3DVP9 D3DVQ0 P22607 Q14308 Q16294 Q16608 Q59FL9

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR001245 (Ser-Thr/Tyr-Pkinase.)
IPR003598 (Ig_sub2.)
IPR003599 (Ig_sub.)
IPR007110 (Ig-like.)
IPR008266 (Tyr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR013098 (Ig_I-set.)
IPR013151 (Immunoglobulin.)
IPR013783 (Ig-like_fold.)
IPR016248 (Tyr_kinase_fibroblast_GF_rcpt.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_Pkinase_cat_dom.)
Pfam PF00047 (ig)
PF07679 (I-set)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1RY7
CREDO 1RY7
spacer
spacer