ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL2742
Target Type SINGLE PROTEIN
Preferred Name Fibroblast growth factor receptor 3
Synonyms CD_antigen=CD333 | FGFR-3 | FGFR3 | Fibroblast growth factor receptor 3 | JTK4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase fgfr family

Target Components

Component Description Relationship Accession
Fibroblast growth factor receptor 3 SINGLE PROTEIN P22607

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095217 Fibroblast growth factor receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1201733 PAZOPANIB HYDROCHLORIDE Fibroblast growth factor receptor 3 inhibitor 4 DailyMed
CHEMBL522892 DOVITINIB Fibroblast growth factor receptor 3 inhibitor 3 PubMed
CHEMBL1908391 MASITINIB Fibroblast growth factor receptor 3 inhibitor 3 Other PubMed PubMed
CHEMBL482968 ENMD-2076 Fibroblast growth factor receptor 3 inhibitor 2 Other PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000068078
Ensembl ENSG00000068078
GO Cellular Component GO:0005576 (extracellular region)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005925 (focal adhesion)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016023 (cytoplasmic, membrane-bounded vesicle)
GO:0030133 (transport vesicle)
GO:0031410 (cytoplasmic vesicle)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005007 (fibroblast growth factor-activated receptor activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016303 (1-phosphatidylinositol-3-kinase activity)
GO:0016740 (transferase activity)
GO:0017134 (fibroblast growth factor binding)
GO:0046934 (phosphatidylinositol-4,5-bisphosphate 3-kinase activity)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0001501 (skeletal system development)
GO:0001958 (endochondral ossification)
GO:0002062 (chondrocyte differentiation)
GO:0003416 (endochondral bone growth)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007259 (JAK-STAT cascade)
GO:0007267 (cell-cell signaling)
GO:0008284 (positive regulation of cell proliferation)
GO:0008543 (fibroblast growth factor receptor signaling pathway)
GO:0010518 (positive regulation of phospholipase activity)
GO:0014066 (regulation of phosphatidylinositol 3-kinase signaling)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030282 (bone mineralization)
GO:0035988 (chondrocyte proliferation)
GO:0036092 (phosphatidylinositol-3-phosphate biosynthetic process)
GO:0042511 (positive regulation of tyrosine phosphorylation of Stat1 protein)
GO:0042517 (positive regulation of tyrosine phosphorylation of Stat3 protein)
GO:0043410 (positive regulation of MAPK cascade)
GO:0043547 (positive regulation of GTPase activity)
GO:0043552 (positive regulation of phosphatidylinositol 3-kinase activity)
GO:0046777 (protein autophosphorylation)
GO:0046854 (phosphatidylinositol phosphorylation)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0048640 (negative regulation of developmental growth)
GO:0060349 (bone morphogenesis)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0070977 (bone maturation)
GO:1902178 (fibroblast growth factor receptor apoptotic signaling pathway)
Wikipedia Fibroblast_growth_factor_receptor_3

Target Cross References - Protein

canSAR P22607
CGD Camptodactyly, tall stature, and hearing loss (CATSHL) syndrome; Crouzon syndrome with acanthosis nigricans; Muenke syndrome
Human Protein Atlas ENSG00000068078
IntAct P22607
Guide to Pharmacology 1810
Open Targets ENSG00000068078
PharmGKB PA28129
Pharos P22607 (Tclin)
Reactome R-HSA-109704 (PI3K Cascade.)
R-HSA-1257604 (PIP3 activates AKT signaling.)
R-HSA-1839130 (Signaling by activated point mutants of FGFR3.)
R-HSA-190371 (FGFR3b ligand binding and activation.)
R-HSA-190372 (FGFR3c ligand binding and activation.)
R-HSA-2033514 (FGFR3 mutant receptor activation.)
R-HSA-2033515 (t(4;14) translocations of FGFR3.)
R-HSA-2219530 (Constitutive Signaling by Aberrant PI3K in Cancer.)
R-HSA-5654227 (Phospholipase C-mediated cascade, FGFR3.)
R-HSA-5654704 (SHC-mediated cascade:FGFR3.)
R-HSA-5654706 (FRS-mediated FGFR3 signaling.)
R-HSA-5654710 (PI-3K cascade:FGFR3.)
R-HSA-5654732 (Negative regulation of FGFR3 signaling.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
R-HSA-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
R-HSA-8853334 (Signaling by FGFR3 fusions in cancer.)
R-HSA-8853338 (Signaling by FGFR3 point mutants in cancer.)
UniProt D3DVP9 D3DVQ0 P22607 Q14308 Q16294 Q16608 Q59FL9

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR003598 (Ig_sub2.)
IPR003599 (Ig_sub.)
IPR007110 (Ig-like_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR013098 (Ig_I-set.)
IPR013783 (Ig-like_fold.)
IPR016248 (FGF_rcpt_fam.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR028176 (FGF_rcpt_3.)
Pfam PF07679 (I-set)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1RY7 4K33
CREDO 1RY7 4K33
spacer
spacer