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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL274
Preferred Name C-C chemokine receptor type 5
Synonyms C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5 | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > chemokine receptor > cc chemokine receptor

Target Components

Component Description Relationship Accession
C-C chemokine receptor type 5 SINGLE PROTEIN P51681

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3301384 CCR5/mu opioid receptor complex PROTEIN COMPLEX

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL1201187 MARAVIROC C-C chemokine receptor type 5 antagonist DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000160791
Ensembl ENSG00000160791
GO Cellular Component GO:0005768 (endosome)
GO:0005887 (integral to plasma membrane)
GO:0009897 (external side of plasma membrane)
GO Molecular Function GO:0003779 (actin binding)
GO:0004435 (phosphatidylinositol phospholipase C activity)
GO:0015026 (coreceptor activity)
GO:0016493 (C-C chemokine receptor activity)
GO Biological Process GO:0002407 (dendritic cell chemotaxis)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0006968 (cellular defense response)
GO:0007204 (elevation of cytosolic calcium ion concentration)
GO:0007267 (cell-cell signaling)
GO:0019059 (initiation of viral infection)
GO:0030260 (entry into host cell)
Wikipedia CCR5

Target Cross References - Protein

canSAR P51681
Human Protein Atlas ENSG00000160791
IntAct P51681
Guide to Pharmacology 62 (CCR5)
PharmGKB PA26170
Reactome REACT_14797 (Signaling by GPCR.)
REACT_6185 (HIV Infection.)
UniProt O14692 O14693 O14695 O14696 O14697 O14698 O14699 O14700 O14701 O14702 O14703 O14704 O14705 O14706 O14707 O14708 O15538 P51681 Q9UPA4

Target Cross References - Domain

InterPro IPR000276 (7TM_GPCR_Rhodpsn.)
IPR000355 (Chemokine_rcpt.)
IPR002240 (Chemokine_CCR5.)
IPR017452 (GPCR_Rhodpsn_supfam.)
Pfam PF00001 (7tm_1)