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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2738
Target Type SINGLE PROTEIN
Preferred Name Acrosin
Synonyms ACR | ACRS | Acrosin heavy chain | Acrosin light chain | Acrosin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Acrosin SINGLE PROTEIN P10323

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100312 ENSG00000283539
Ensembl ENSG00000100312 ENSG00000283539
GO Cellular Component GO:0001669 (acrosomal vesicle)
GO:0005576 (extracellular region)
GO:0005634 (nucleus)
GO:0005798 (Golgi-associated vesicle)
GO:0032991 (macromolecular complex)
GO:0043159 (acrosomal matrix)
GO Molecular Function GO:0002020 (protease binding)
GO:0003677 (DNA binding)
GO:0004040 (amidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0005507 (copper ion binding)
GO:0005515 (protein binding)
GO:0005537 (mannose binding)
GO:0008144 (drug binding)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0042806 (fucose binding)
GO Biological Process GO:0002077 (acrosome matrix dispersal)
GO:0006508 (proteolysis)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007338 (single fertilization)
GO:0007339 (binding of sperm to zona pellucida)
GO:0007340 (acrosome reaction)
GO:0007341 (penetration of zona pellucida)
GO:0048545 (response to steroid hormone)
Wikipedia Acrosin

Target Cross References - Protein

canSAR P10323
Human Protein Atlas ENSG00000100312 ENSG00000283539
Guide to Pharmacology 2327
Open Targets ENSG00000100312 ENSG00000283539
PharmGKB PA24451
Reactome R-HSA-1300645 (Acrosome Reaction.)
UniProt P10323 Q6ICK2

Target Cross References - Domain

InterPro IPR001254 (Trypsin_dom.)
IPR001314 (Peptidase_S1A.)
IPR009003 (Peptidase_S1_PA.)
IPR012267 (Pept_S1A_acrosin.)
IPR018114 (TRYPSIN_HIS.)
IPR033116 (TRYPSIN_SER.)
Pfam PF00089 (Trypsin)
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